2016-Présent : CNRS ISM/Université de Bordeaux 2008-2016 : CNRS, unités mixtes CNRS-Pierre Fabre UMS 2597, USR 3388(Toulouse) Dr G.Massiot/Dr P. B. Arimondo. 2007-2008 : A.T.E.R, Institut de Chimie Moléculaire de Paris-Est (ICMPE-Thiais) , Pr J-Y. Nédélec. 2006-2007 : A.T.E.R, EnsiCaen /Université de Basse-Normandie (Caen), Pr P.Metzner. 2005-2006 : Post-doc, Frei Universität (Berlin), Pr H-U Reissig. 2000-2004 : Doctorat de l’Université Joseph Fourier (Grenoble), Pr. Y. Vallée. 1999-2000 : D.E.A. de l’Université Pierre et Marie Curie (Paris 6), Dr H Rudler
Activités de recherche
Les recherches en cours sont axées sur la synthèse totale ou hémisynthèse de molécules naturelles ayant des activités biologiques, tout aussi bien en oncologie qu’en neurologie, ainsi que le développement de différentes méthodologies utiles pour préparer des analogues et établir des Relations Structures-Activités de ces familles de molécules.
Contact
frederic.cantagrel@u-bordeaux.fr
frederic.cantagrel@cnrs.fr
tél : 05 40 00 24 26
Bât. A12, 1er ét. ouest, ISM, UMR-CNRS 5255, Groupe Catalysis, Synthesis and Health
Université Bordeaux 1, 351, cours de la libération, 33405 TALENCE Cedex
Publications
Paul, J., Presset, M., Cantagrel, F., Le Gall, E., Léonel, E. (). Cobalt-Catalyzed Reductive Multicomponent Synthesis of β-Hydroxy- and β-Aminocarbonyl Compounds under Mild Conditions. In Chemistry - A European Journal (Vol. 23, Issue 2, p. 402-406). https://doi.org/10.1002/chem.201604251
Kaloun, E.B., Long, C., Molinier, N., Brel, V., Cantagrel, F., Massiot, G. (). Partial synthesis of 14-deoxy-14-aminotriptolide. In Tetrahedron Letters (Vol. 57, Issue 17, p. 1895-1898). https://doi.org/10.1016/j.tetlet.2016.03.060
Gros, C., Fleury, L., Nahoum, V., Faux, C., Valente, S., Labella, D., Cantagrel, F., Rilova, E., Bouhlel, M.A., David-Cordonnier, M.H., Dufau, I., Ausseil, F., Mai, A., Mourey, L., Lacroix, L., Arimondo, P.B. (). New insights on the mechanism of quinoline-based DNA methyltransferase inhibitors. In Journal of Biological Chemistry (Vol. 290, Issue 10, p. 6293-6302). https://doi.org/10.1074/jbc.M114.594671
Erdmann, A., Halby, L., Cantagrel, F., Sautel, F., Massiot, G., Arimondo, P.B. (). Alternative synthetic route to annulated diaminopyrimidines. In Tetrahedron Letters (Vol. 55, Issue 29, p. 3901-3904). https://doi.org/10.1016/j.tetlet.2014.05.057
Rilova, E., Erdmann, A., Gros, C., Masson, V., Aussagues, Y., Poughon-Cassabois, V., Rajavelu, A., Jeltsch, A., Menon, Y., Novosad, N., Gregoire, J.M., Vispé, S., Schambel, P., Ausseil, F., Sautel, F., Arimondo, P.B., Cantagrel, F. (). Design, synthesis and biological evaluation of 4-Amino-N-(4-aminophenyl) benzamide analogues of quinoline-based SGI-1027 as inhibitors of DNA methylation. In ChemMedChem (Vol. 9, Issue 3, p. 590-601). https://doi.org/10.1002/cmdc.201300420
Long, C., Beck, J., Cantagrel, F., Marcourt, L., Vendier, L., David, B., Plisson, F., Derguini, F., Vandenberghe, I., Aussagues, Y., Ausseil, F., Lavaud, C., Sautel, F., Massiot, G. (). Proteasome inhibitors from Neoboutonia melleri. In Journal of Natural Products (Vol. 75, Issue 1, p. 34-47). https://doi.org/10.1021/np200441h
Beck, J., Guminski, Y., Long, C., Marcourt, L., Derguini, F., Plisson, F., Grondin, A., Vandenberghe, I., Vispé, S., Brel, V., Aussagues, Y., Ausseil, F., Arimondo, P.B., Massiot, G., Sautel, F., Cantagrel, F. (). Semisynthetic neoboutomellerone derivatives as ubiquitin-proteasome pathway inhibitors. In Bioorganic and Medicinal Chemistry (Vol. 20, Issue 2, p. 819-831). https://doi.org/10.1016/j.bmc.2011.11.066
Davoust, M., Cantagrel, F., Metzner, P., Brière, J.F. (). A stereodivergent synthesis of β-hydroxy-α-methylene lactones via vinyl epoxides. In Organic and Biomolecular Chemistry (Vol. 6, Issue 11, p. 1981-1993). https://doi.org/10.1039/b802310g
Pernet-Poil-Chevrier, A., Cantagrel, F., Jeune, K.L., Philouze, C., Chavant, P.Y. (). New chiral nitrones as precursors of α,α-disubstituted amino-acids, according to the SRS principle. In Tetrahedron Asymmetry (Vol. 17, Issue 13, p. 1969-1974). https://doi.org/10.1016/j.tetasy.2006.06.046
Fischer, A., Müller, D., Zimmermann-Kordmann, M., Kleuser, B., Mickeleit, M., Laabs, S., Löwe, W., Cantagrel, F., Reutter, W., Danker, K. (). The ether lipid inositol-C2-PAF is a potent inhibitor of cell proliferation in HaCaT cells. In ChemBioChem (Vol. 7, Issue 3, p. 441-449). https://doi.org/10.1002/cbic.200500336
Cantagrel, F., Pinet, S., Gimbert, Y., Chavant, P.Y. (). Tandem addition/cyclization of alkynylzinc reagents to enantiopure 2-tert-butyl-3,5-dimethyl-2,3-dihydroimidazol-4-one N-oxide: Potential precursors of quaternary α-amino acids. In European Journal of Organic Chemistry (Issue 13, p. 2694-2701). https://doi.org/10.1002/ejoc.200400861
Rudler, H., Harris, P., Parlier, A., Cantagrel, F., Denise, B., Bellassoued, M., Vaissermann, J. (). Transition-metal catalyzed synthesis of δ-hydroxy-γ-lactones from bis(trimethylsilyl) ketene acetals and allylic acetates via γ-unsaturated carboxylic acids. Comments on the formation of α-cyclopropyl carboxylic acids. In Journal of Organometallic Chemistry (Vol. 624, Issue 1-2, p. 186-202). https://doi.org/10.1016/S0022-328X(00)00905-0
Rudler, H., Parlier, A., Cantagrel, F., Harris, P., Bellassoued, M. (). A two-step, catalytic synthesis of δ-hydroxy-γ-lactones from allylic acetates and bis(trimethylsilyl)ketene acetals. In Chemical Communications (Issue 9, p. 771-772). https://doi.org/10.1039/b001175o