We are developing fluorescent organic nanoparticles for use as biomarkers or biosensors. To this end, the surface of the nanoparticles must be decorated with specific bioreceptors such as proteins, antibodies or oligonucleotides. We are paying particular attention to minimise the size of functionalised nanoparticles in order to guarantee a degree of stealth for in vivo applications (biomarkers), or to optimise energy transfer to other fluorophores (biosensors – see Figure). To this end, we are developing original approaches for the synthesis and assembly of nano-objects, using supramolecular, click or polymer chemistry.
Part of this projects belongs to the ERC COMET
Interested in the COMET project? Please contact Chloé GRAZON
The COMET team:
- Ophélie Dal Pra, PhD [2021-2024]
- Amin El Jarroudi-Hammou, PhD [2023-2026]
- Clara Catros, PhD [2024-2027]
- Vincent Mariani, PhD [2024-2027]
- Dalel El Marrouki, post-doc [2024-2025]
Publications related to this project:
- Inter-Nanoparticle FRET for Biosensing: Photophysics Versus Size
- Two-photon Dye-Based Fluorogenic Organic Nanoparticles as Intracellular Thiols Sensors
- The quantum dot vs. organic dye conundrum for ratiometric FRET-based biosensors: which one would you chose?
- A progesterone biosensor derived from microbial screening
- Aqueous Ring-Opening Polymerization-Induced Self-Assembly (ROPISA) of N-Carboxyanhydrides
- A versatile and accessible polymer coating for functionalizable zwitterionic quantum dots with high DNA grafting efficiency
Mots-clés
- ERC
- Biosenseurs
- Fluorescence
- Nanoparticule