Molecular MRI team (Yannick Crémillieux)

The research activities of the team are focused on innovative methodological and instrumental developments for applications in the field of biomedical MRI :

  • Dynamic Nuclear Polarization techniques for highly sensitive in vivo MRI protocols : hyperpolarization of Carbon-13 labelled metabolites (pyruvate, lactate) and metabolic MRI/MRS studies
  • Methodological and instrumentation developments for molecular MRI : micro-coil for the quantification of brain metabolites, theranostics contrast agents for lung MRI

Permanent staff

  • Yannick Crémillieux (Senior Researcher CNRS)
  • Noël Pinaud (Technician UB)

Non permanent staff

  • Vanessa Zhendre (NMR engineer)
  • Silvia Rizzitelli (2015-2016) Postdoctoral position
  • Stefan Glöggler (2015) Postodoctoral position

Selection of recent publications

Moussaron A, Vibhute S, Bianchi A, Gündüz S, Kotb S, Sancey L, Motto-Ros V, Rizzitelli S, Crémillieux Y, Lux F, Logothetis NK, Tillement O, Angelovski G. Ultrasmall Nanoplatforms as Calcium-Responsive Contrast Agents for Magnetic Resonance Imaging. Small. 2015 Oct 7 ;11(37):4900-9.

Bianchi A, Moncelet D, Lux F, Plissonneau M, Rizzitelli S, Ribot EJ, Tassali N, Bouchaud V, Tillement O, Voisin P, Crémillieux Y. Orotracheal administration of contrast agents : a new protocol for brain tumor targeting. NMR Biomed. 2015 Jun ;28(6):738-46.

Lux F, Sancey L, Bianchi A, Crémillieux Y, Roux S, Tillement O. Gadolinium-based nanoparticles for theranostic MRI-radiosensitization. Nanomedicine (Lond). 2015 ;10(11):1801-15.

Dufort S, Bianchi A, Henry M, Lux F, Le Duc G, Josserand V, Louis C, Perriat P, Crémillieux Y, Tillement O, Coll JL. Nebulized gadolinium-based nanoparticles : a theranostic approach for lung tumor imaging and radiosensitization. Small. 2015 Jan 14 ;11(2):215-21.

Bianchi A, Dufort S, Lux F, Fortin PY, Tassali N, Tillement O, Coll JL, Crémillieux Y. Targeting and in vivo imaging of non-small-cell lung cancer using nebulized multimodal contrast agents. Proc Natl Acad Sci U S A. 2014 Jun 24 ;111(25):9247-52.

Bianchi A, Dufort S, Fortin PY, Lux F, Raffard G, Tassali N, Tillement O, Coll JL, Crémillieux Y. In vivo MRI for effective non-invasive detection and follow-up of an orthotopic mouse model of lung cancer. NMR Biomed. 2014 Aug ;27(8):971-9.

Bianchi A, Dufort S, Lux F, Courtois A, Tillement O, Coll JL, Crémillieux Y. Quantitative biodistribution and pharmacokinetics of multimodal gadolinium-based nanoparticles for lungs using ultrashort TE MRI. MAGMA. 2014 Aug ;27(4):303-16.

Lederlin M, Crémillieux Y. Three-dimensional assessment of lung tissue density using a clinical ultrashort echo time at 3 tesla : a feasibility study in healthy subjects. J Magn Reson Imaging. 2014 Oct ;40(4):839-47.

Bianchi A, Ozier A, Ousova O, Raffard G, Crémillieux Y. Ultrashort-TE MRI longitudinal study and characterization of a chronic model of asthma in mice : inflammation and bronchial remodeling assessment. NMR Biomed. 2013 Nov ;26(11):1451-9.

Bianchi A, Lux F, Tillement O, Crémillieux Y. Contrast enhanced lung MRI in mice using ultra-short echo time radial imaging and intratracheally administrated Gd-DOTA-based nanoparticles. Magn Reson Med. 2013 Nov ;70(5):1419-26.

Gobbo OL, Zurek M, Tewes F, Ehrhardt C, Crémillieux Y. Manganese : a new contrast agent for lung imaging ? Contrast Media Mol Imaging. 2012 Nov-Dec ;7(6):542-6.

Zurek M, Boyer L, Caramelle P, Boczkowski J, Crémillieux Y. Longitudinal and noninvasive assessment of emphysema evolution in a murine model using proton MRI. Magn Reson Med. 2012 Sep ;68(3):898-904.

Cremillieux Y, Goutailler F, Montcel et al. A Super-Wide Bore DNP System for Multiple Sample Polarization : Cryogenic Performance and Polarization at Low Temperature. Applied Magnetic Resonance Volume : 43 Issue : 1-2 Pages : 167-180 Published : JUL 2012

Al Faraj A, Fauvelle F, Luciani N, Lacroix G, Levy M, Crémillieux Y, Canet-Soulas E. In vivo biodistribution and biological impact of injected carbon nanotubes using magnetic resonance techniques. Int J Nanomedicine. 2011 ;6:351-61.

Bannier E, Cieslar K, Mosbah K, Aubert F, Duboeuf F, Salhi Z, Gaillard S, Berthezène Y, Crémillieux Y, Reix P. Hyperpolarized 3He MR for sensitive imaging of ventilation function and treatment efficiency in young cystic fibrosis patients with normal lung function. Radiology. 2010 Apr ;255(1):225-32.

Zurek M, Bessaad A, Cieslar K, Crémillieux Y. Validation of simple and robust protocols for high-resolution lung proton MRI in mice. Magn Reson Med. 2010 Aug ;64(2):401-7.

Al Faraj A, Cieslar K, Lacroix G, Gaillard S, Canet-Soulas E, Crémillieux Y. In vivo imaging of carbon nanotube biodistribution using magnetic resonance imaging. Nano Lett. 2009 Mar ;9(3):1023-7.

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