Imagerie et Photonique Moléculaire

L’équipe "Imagerie et Photonique Moléculaire" est animée par Mireille Blanchard-Desce.

Membres permanents de l’équipe :

Membres non-permanents de l’équipe :

  • Antoni BAUTISTA BARRUFET - postdoctorant
  • Eduardo CUETO DIAZ - postdoctorant
  • Jonathan DANIEL - postdoctorant
  • Petra IVASKOVIC - doctorante
  • Maxime KLAUSEN - doctorant
  • Adina LAZAR - postdoctorante
  • Cristiano Matteo MASTRODONATO - doctorant
  • Paolo PAGANO - doctorant
  • Sébastien PICARD -postdoctorant



6. "Fluorescent phosphorus dendrimers excited by two photons : synthesis, two-photon absorption properties and biological uses", A.-M. Caminade, A. Zibarov, E. Cueto Diaz, A. Hameau, M. Klausen, K. Moineau-Chane Ching, J.-P. Majoral, J.-B. Verlhac, O. Mongin, M. Blanchard-Desce, Beilstein J. Org. Chem., accepté (07/2019).

5. “Further studies on the photoreactivities of ruthenium-nitrosyl complexes with terpyridyl ligands”, I. Sasaki*, S. Amabilino, S. Mallet-Ladeira, M. Tassé, A. Sournia-Saquet, P.G. Lacroix, I. Malfant*, New. J. Chem., 2019, DOI : 10.1039/C9NJ02398D

4. "Tandem Systems for Two-Photon Uncaging of Bioactive Molecules", M. Klausen, V. Dubois, J.-B. Verlhac*, M. Blanchard-Desce*, ChemPlusChem., 2019, 84, 589-598. DOI : 10.1002/cplu.201900139 (invited minireview).

3. "Dual-wavelength efficient two-photon photorelease of glycine by π-extended dipolar coumarins", M. Klausen, V. Dubois, G. Clermont, C. Tonnelé, F. Castet, M. Blanchard-Desce*, Chem. Sci., 2019, 10, 4209-4219. DOI : 10.1039/C9SC00148D

2. "Dendrimeric nanoparticles for two-photon photodynamic therapy and imaging : synthesis, photophysical properties, innocuousness in daylight and cytotoxicity under two-photon irradiation in the NIR", A. Sourdon, M. Gary-Bobo, M. Maynadier, M. Garcia, J.-P. Majoral, A.-M. Caminade, O. Mongin*, M. Blanchard-Desce*, Chem. Eur. J., 2019. DOI : 10.1002/chem.201805617.

1. "Synthesis of Bis(arylethynyl)pyrrolo[3,2‐b]pyrroles and an Effect of Intramolecular Charge‐transfer on Their Photophysical Behavior", M. Tasior, G. Clermont, M. Blanchard-Desce,* D. Jacquemin,* D. T Gryko,* Chem. Eur. J., 2019, 25, 598-608. DOI : 10.1002/chem.201804325


7. "Harnessing lysosomal pH through PLGA nanoemulsion as a treatment of lysosomal-related neurodegenerative diseases", G. Prévot, F. N. Soria, M.-L. Thiolat, J. Daniel, J. B. Verlhac, M. Blanchard-Desce*, E. Bezard, P. Barthélémy, S. Crauste-Manciet, B. Dehay, Bioconjugate Chem., 2018, 29, 4083-4089. DOI : 10.1021/acs.bioconjchem.8b00697

6. "Spectral dependence of plasmon-enhanced fluorescence in a hollow nanotriangle assembled by DNA origami : towards plasmon assisted energy transfer", P. Ivaskovic, A. Yamada, J. Elezgaray, D. Talaga, S. Bonhommeau, M. Blanchard-Desce, R. A. L. Vallée, S. Ravaine, Nanoscale, 2018, 10, 16568-16573. DOI : 10.1039/c8nr04426k

5. "Diphenylamino-substituted Tristyryl vs. Triphenyl Isocyanurates : Improved Conjugation has Minimal Impact on Two-Photon Absorption", A. Triadon, A. Ngo Ndimba, N. Richy, A. Amar, A. Boucekkine, T. Roisnel, M. P. Cifuentes, M. G. Humphrey, M. Blanchard-Desce, O. Mongin, F. Paul, New. J. Chem., 2018, 42, 11289-11293. DOI : 10.1039/c8nj01904e.

4. "In vivo functionalization of biosilica from Thalassiosira weissflogii with a two-photon red emitting fluorescent tag", D. Vona, G. Leone, M. Lo Presti, R. Ragni, J. Daniel, M. Blanchard-Desce, G. M. Farinola, S. R. Cicco, MRS Adv. 2018, 3 (Issue 29, Biomaterials and Soft Materials), 1611-1620. DOI : 10.1557/adv.2018.162.

3. "New Conjugated meso-Tetra(thien-2-yl)porphyrin-Cored Derivatives as Two-photon Photosensitizers for Singlet Oxygen Generation", X. Zhang, S. Abid, L. Shi, Z. Sun, O. Mongin, M. Blanchard-Desce, F. Paul, C. O. Paul-Roth, Dyes and Pigments, 2018, 153, 248-255.DOI : 10.1016/j.dyepig.2018.01.028

2. "New Porphyrin-based Dendrimers with alkene linked Fluorenyl Antennae for Optics", Yao Dandan , Zhang Xu, Abid Seifallah, Shi Limiao, Blanchard-Desce Mireille , Mongin Olivier, Paul Frederic, Paul-Roth Christine, New J. Chem., 2018, 42, 395-401.DOI : 10.1039/C7NJ03522E.

1. "Linear and Nonlinear Optical Properties of Tricyanopropylidene-based Merocyanine Dyes : Synergistic Experimental and Theoretical Investigations", V. Parthasarathy, R. Pandey, P. K. Das*, F. Castet*, M. Blanchard-Desce*, Chem. Phys. Chem., 2018, 19, 187-197. DOI : 10.1002/chem.201603510.


9. "Quinoline-derived two-photon sensitive octupolar probes", P. Dunkel, M. Petit, H. Dhimane, M. Blanchard-Desce, D. Ogden, P. I. Dalko, ChemistryOpen. 2017, 6, 660. DOI : 10.1002/open.201700097

8. "BF2 complexes of 1,3-diketones on the surface of phosphorus dendrimers. Synthesis and study of the photoluminescence properties", C. Rouxel, O. Mongin, A. Hameau, A. Ouali, M. Blanchard-Desce, J.-P. Majoral, A.-M. Caminade, Can. J. Chem., 2017, 95, 948-953.

7. "Synthesis and optical properties of water soluble diketopyrrolopyrroles", M. Grzybowski, E. Glodkowska-Mrowka, G. Clermont, M. Blanchard-Desce,* D. T. Gryko,* Chemistry of Heterocyclic Compounds, 2017, 53, 72-77.

6. "The promising first-in-class anticancer copper(II) phosphorus dendrimers are potent proapoptotic Bax activators", S. Mignani, N. El Brahmi, L. Eloy, J. Poupon, V. Nicolas, A. Steinmetz, S. El Kazzouli, M. M. Bousmina, M. Blanchard-Desce, A.-M. Caminade, J.-P. Majoral, T. Cresteil, European Journal of Medicinal Chemistry, 2017, 132, 142-156.

5. "Functionalized Ruthenium Complexes : Selective “Turn-on” Detection of Biologically Relevant Anionic Species", E. Berni, L. Le Henaff, L. Jarrige, E. Girard, G. Jonusauskas, I. Gosse,* S. Pinet*, Eur. J. Org. Chem. 2017, 3620-3630.

4. "New Conjugated meso-Tetrafluorenylporphyrin-cored Derivatives as Fluorescent Two-Photon Photosensitizers for Singlet Oxygen Generation", D. Yao, X. Zhang, A. Triadon, N. Richy, O. Mongin, M. Blanchard-Desce, F. Paul, C.O. Paul-Roth, Chem. Eur. J., 2017, 23, 2635-2647. DOI : 10.1002/chem.201604654.

3. "The Impact of the Interplay between Steric and Electronic Effects on the Synthesis and the Optical Properties of Diketopyrrolopyrroles bearing Pyridine Moieties", O. Vakuliuk, A. Purc, G. Clermont, M. Blanchard-Desce,* D. T. Gryko,* Chem. Photochem., 2017, 1, 243-252. DOI : 10.1002/cptc.201600047.

2. "Cooperative porphyrin-quadrupolar based triad for combined two-photon induced fluorescence and singlet oxygen generation", J.-B. Verlhac, G. Clermont, M. Blanchard-Desce, Journal of Porphyrins and Phthalocyanines, 2017, 21, 77-87. Cover

1. Quinoline-Derived Two-Photon Sensitive Quadrupolar Probes, C. Tran, N. Berqouch, H. Dhimane, G. Clermont, M. Blanchard-Desce, D. Ogden, P. I. Dalko, Chem. Eur. J., 2017, 23, 1860-1868. DOI : 10.1002/chem.201604500.


22. "Chemistry and Applications of Supramolecular Graphene Derivatives" in Graphene Science Handbook vol 6 Applications and Industrialization , H. Bares, J.-B. Verlhac, D. Bassani, CRC Press 2016, Eds. M. Aliofkhazraei, N. Ali, W.I. Milne, C.S. Ozkan, S. Mitura, J. L. Gervasoni, pp. 337–352.

21. "Synthesis, Optical and Theoretical Study of Alternated Ethylenedioxythiophene-pyridine Oligomers : Evolution from Planar Conjugated over Helicoidal towards Chiral Configuration", F. Chevallier, M. Charlot, F. Mongin, B. Champagne, E. Franz, K. Clays, M. Blanchard-Desce, Chem. Phys. Chem., 2016, 17, 4090-4101. DOI : 10.1002/cphc.201601057

20. "trans‐ and cis‐(Cl,Cl)‐[RuII(FT)Cl2(NO)](PF6) : Promising candidates for NO release in the NIR region", J. Akl, I. Sasaki, P. G. Lacroix, V. Hugues, P. Vicendo, M. Bocé, S. Mallet-Ladeira, M. Blanchard-Desce*, I. Malfant*, Photochem. Photobiol. Sci., 2016, 15, 1484-1491. DOI : 10.1039/C6PP00181E

19. "Excited-state symmetry breaking of linear quadrupolar chromophores : A transient absorption study", N. Dozova, L.Ventelon, G. Clermont, M. Blanchard-Desce,* P. Plaza,* Chem. Phys. Lett., 2016, 664, 56–62.

18. "Molecular-based fluorescent nanoparticles built from dedicated dipolar thienothiophene dyes as ultra-bright green to NIR nanoemitters", C. Mastrodonato, P. Pagano, J. Daniel, M. Vaultier, M. Blanchard-Desce*, Molecules, 2016, 21, 1227-1252. DOI:10.3390/molecules21091227. Invited paper in the special issue “Molecular imaging probes”.

17. "Synthesis, fluorescence and two-photon absorption properties of novel push-pull 5-aryl[3,2-b]thienothiophene derivatives", M. Manuela M. Raposo, C. Herbivo, V. Hugues, G. Clermont, M. Cidália R. Castro, A. Comel, M. Blanchard-Desce, Eur. J. Org. Chem. 2016, 5263-5273. DOI : 10.1002/ejoc.201600806

16. "Water-Soluble Triarylborane Chromophores for One- and Two-Photon Excited Fluorescence Imaging of Mitochondria in Cells", S. Griesbeck, Z. Zhang, M. Gutmann, T. Lühmann, R.M. Edkins, G. Clermont, A.N. Lazar, M. Haehnel, K. Edkins, A. Eichhorn, M. Blanchard-Desce,* L. Meinel,* T.B. Marder,* Chem. Eur. J, 2016, 22, 14701-14706. DOI : 10.1002/chem.201602639

15. "Cooperative veratryle and nitroindoline cages for two-photon uncaging in the NIR", E. Cueto Diaz, S. Picard, M. Klausen, V. Hugues, P. Pagano, E. Genin, M. Blanchard-Desce*, Chem. Eur. J, 2016, 22, 10681-11083. DOI : 10.1002/chem.201601109. Hot paper. Inside cover

14. "Bright Electrogenerated Chemiluminescence of a Bis-donor Quadrupolar Spirofluorene Dye and its Nanoparticles", H. Li, J. Daniel, J.-B. Verlhac, M. Blanchard-Desce*, N. Sojic*, Chem. Eur. J, 2016, 22, 36, 12702-12714. DOI : 10.1002/chem.201600413. Hot paper. Frontispice

13. "Fluorescent Periodic Mesoporous Organosilica Nanoparticles Dual-Functionalized via Click Chemistry for Two-Photon Photodynamic Therapy in Cells", J. G. Croissant, S. Picard, D. Aggad, M. Klausen, C. Mauriello Jimenez, O. Mongin, M. Maynadier, G. Clermont, E. Genin, X. Cattoën, M. Wong Chi Man, L. Raehm, M. Garcia, M. Gary-Bobo, M. Blanchard-Desce,* J.-O. Durand,* J. Mater. Chem. B., 2016, 4, 5567-5574. DOI : 10.1039/c6tb00638h

12. "Innovative molecular-based fluorescent nanoparticles for multicolor single particle tracking in cells", J. Daniel, A. Godin, M. Palayret, B. Lounis, L. Cognet, M. Blanchard-Desce, J. Phys. D : Appl. Phys., 2016, 49, 084002. DOI:10.1088/0022-3727/49/8/084002

11. "Enhanced two-photon brightness in molecular-based organic nanoparticles built from articulated-dipoles", J.-B. Verlhac, J. Daniel, P. Pagano, G. Clermont, M. Blanchard-Desce, C. R. Chimie, 2016, 19, 28-38. DOI : 10.1016/j.crci.2015.07.011 (special issue “Emerging Chemistry in France”).

10. "Z-Shaped Pyrrolo[3,2-b]pyrroles and Their Transformation into -Expanded Indolo[3,2-b]indoles", R. Stężycki, M.Grzybowski, G. Clermont, M. Blanchard-Desce,* D. T. Gryko,* Chem. Eur. J, 2016, 22, 5198-5203. DOI : 10.1002/chem.201505052. Hot paper. Back cover.

9. "Unprecedented intramolecular cyclization in strongly dipolar extended merocyanine dyes : a route to novel dyes with improved transparency, nonlinear optical properties and thermal stability", V. Parthasarathy, F. Castet, R. Pandey, O. Mongin, P. K. Das, M. Blanchard-Desce, Dyes and Pigments, 2016, 130, 70-78.

8. "In vitro imaging of -cells using fluorescent cubic bicontinuous liquid crystalline nanoparticles", V. Miceli, V. Meli, M. Blanchard-Desce, T. Bsaibess, M. Pampalone, P. G. Conaldi, C. Caltagirone, M. Obiols-Rabasa, J. Schmidt, Y. Talmon, A. Casuf, S. Murgia, RSC Advances, 2016, 6, 62119-62127. DOI : 10.1039/c6ra09616f.

7. "Iron and Ruthenium Alkynyl Complexes with 2-Fluorenyl Groups : Some Linear and Nonlinear Optical Absorption Properties", F. Malvolti, C. Rouxel, G. Grelaud, L. Toupet, T. Roisnel, A. Barlow, F. I. Abdul Razak, R. Stranger, M. P. Cifuentes, M. G. Humphrey, O. Mongin, M. Blanchard-Desce, C. Paul-Roth, F. Paul, Eur. J. Inorg. Chem., 2016, 3868-3882. DOI : 10.1002/ejic.201600598
6. "Synthesis and Structural Studies of Gallium(III) and Iron(III) Hemicryptophane Complexes". I. Gosse, K. Robeyns, C. Bougault, A. Martinez, B. Tinant, J.-P. Dutasta, Inorg. Chem., 2016, 55, 1011-1013.

5. "Nanoparticles restore lysosomal acidification defects : Implication for Parkinson’s and other lysosomal-related diseases", M. Bourdenx, J. Daniel, E. Genin, M. Blanchard-Desce, E. Bézard, B. Dehay, Autophagy, 2016, 12, 3, 472-483. DOI:10.1080/15548627.2015.1136769. News :

4. "Strongly solvatofluorochromic, non-centrosymmetric π-expanded diketopyrrolopyrrole", M. Grzybowski, A. Jeżewski, I. Deperasińska, D. H. Friese, M. Banasiewicz, V. Hugues, B. Kozankiewicz, M. Blanchard-Desce*, D. T. Gryko*, Org. Biomol. Chem., 2016, 14, 2025-233. DOI : 10.1039/C5OB02583D

3. "Multifunctional Gold-Mesoporous Silica Nanocomposites for Enhanced Two-Photon Imaging and Therapy of Cancer Cells", J. G Croissant, C. Qi, M. Maynadier, X. Cattoën, M. Wong Chi Man, L. Raehm, O. Mongin, M. Blanchard-Desce, M. Garcia, M. Gary-Bobo, J.-O. Durand, Front. Mol. Biosci., 2016, 3:1. DOI : 10.3389/fmolb.2016.00001

2. "Steric and Electronic Effects on the Optical and Photophysical Properties of Anisole- and Cyanobenzene-Substituted Perylene Diimides", B. Pagoaga, O. Mongin, M. Caselli, D. Vanossi, F. Momicchioli, M. Blanchard-Desce, G. Lemercier, N. Hoffmann, G. Ponterini, Phys. Chem. Chem. Phys., 2016, 18, 4924. DOI : 10.1039/c5cp07758c

1. "Linear Optical and Third-Order Nonlinear Optical Properties of Some Fluorenyl- and Triarylamine-Containing Tetracyano-butadiene Derivatives", Z. Pokladek, N. Ripoche, M. Betou, Y. Trolez, O. Mongin, J. Olesiak-Banska, K. Matczyszyn, M. Samoc, M. G. Humphrey, M. Blanchard-Desce, F. Paul, Chem. Eur. J, 2016, 22, 10155-10167. DOI : 10.1002/chem.201600897


1. Sponge-like ionic liquids : a new platform for green biocatalytic chemical processes, P. Lozano, J.M. Bernal, E. Garcia-Verdugo,G. Sanchez-Gomez, M. Vaultier, M. I. Burguete, L., V. Santiago, Green Chem. 2015, 17, 3706-3717. DOI:10.1039/C5GC00894H

2. "Cooperative Dyads for Two-Photon Uncaging", E. J. Cueto Díaz, S. Picard, V. Chevasson, J. Daniel, V. Hugues, O. Mongin, E. Genin, M. Blanchard-Desce, Org. Lett. 2015, 17, 102-105. DOI : org/10.1021/ol5033046.

3. "pKa tuning in quadrupolar-type two-photon ratiometric fluorescent membrane probes", J. Daniel, C. Mastrodonato, A. Sourdon, G. Clermont, J.-M. Vabre, B. Goudeau, H. Voldoire, S. Arbault, O. Mongin, M. Blanchard-Desce, Chem. Comm., 2015, 51, 15245-15248. DOI : 10.1039/c5cc04573h. Inside back cover.

4. "Combination of Cyanine Behaviour and Giant Hyperpolarisability in Novel Merocyanine Dyes : Beyond the BLA Paradigm", V. Parthasarathy, R. Pandey, M. Stolte, S. Ghosh, F. Castet, F. Würthner,* P. K. Das,* M. Blanchard-Desce,* Chem. Eur. J, 2015, 21, 14211-14217. DOI : 10.1002/chem.201501800.

5. "Strong solvent dependence of linear and non-linear optical properties of donor-acceptor type pyrrolo[3,2-b]pyrroles", R. Orłowski, M. Banasiewicz, G. Clermont, F. Castet, R. Nazir, M. Blanchard-Desce*, D. T. Gryko*, Phys. Chem. Chem. Phys., 2015, 17, 23724-23731. DOI : 10.1039/C5CP03523F. Cover

6. "Amplified Two-Photon Brightness in Organic Multicomponent Nanoparticles", E. Campioli, D.-M. Nikolaidou, V. Hugues, M. Campanini, L. Nasi, M. Blanchard-Desce*, F. Terenziani*, J. Mater. Chem. C, 2015, 3, 7483-7491. DOI : 10.1039/C5TC01136A.

7. "Two-photon sensitive protecting groups operating via intramolecular electron transfer : uncaging of GABA and tryptophan", K. A. Korzycka, P. M. Bennett, E. Cueto-Diaz, G. Wicks, M. Drobizhev, M. Blanchard-Desce, A. Rebane, H. L. Anderson, Chem. Sci. 2015, 6, 2419-2426. DOI : 10.1039/C4SC03775H.

8. "Mannose 6-phosphate receptor as new target for theranostic of prostate cancer", O. Vaillant, K. El Cheikh, D. Warther, D. Brevet, M. Maynadier, E. Bouffard, F. Salgues, A. Jeanjean, P. Puche, C. Mazerolles, P. Maillard, O. Mongin, M. Blanchard-Desce, L. Raehm, X. Rebillard, J.-O. Durand, M. Gary-Bobo, A. Morère, M. Garcia, Angew. Chem. Int. Ed. 2015, 54, 5952-5956. DOI : 10.1002/anie.201500286.

9. "Polar diketopyrrolopyrrole-imidazolium salts as selective probes for staining mitochondria in two-photon fluorescence microscopy", M. Grzybowski, E. Glodkowska-Mrowka, Vincent Hugues, Mireille Blanchard-Desce,* D. T. Gryko,* Chem. Eur. J. 2015, 21, 9101-9110. DOI : 10.1002/chem.201500738. Back cover.

10. "Interfacial Organization in Dipolar Dyes-based Organic Nanoparticles probed by Second-Harmonic Scattering", J. Daniel, F. Bondu, F. Adamietz, M. Blanchard-Desce, V. Rodriguez, ACS Photonics, 2015, 2, 1209-1216. DOI : 10.1021/acsphotonics.5b00301.

11. "NIR-emitting molecular-based nanoparticles as new two-photon absorbing nanotools for single particle tracking", J. Daniel, A. G. Godin, G. Clermont, B. Lounis, L. Cognet,* M. Blanchard-Desce,* Proc. SPIE 9523, International Conference on Nano-Bio Sensing, Imaging, and Spectroscopy 2015, 95230M (July 8, 2015) ; DOI:10.1117/12.2189638.

12. "8-Br-quinoline derivatives as sensitizers combining two-photon induced fluorescence and singlet oxygen generation", S. Picard, G. Clermont, E. Genin, M. Blanchard-Desce, Tetrahedron, 2015, 71, 1088-1094.

13. Biocatalysis in ionic liquids (Edited By:Dupont, Jairton). P. Lozano, J. M. Bernal, E. Garcia-Verdugo, M. Vaultier, S. V. Luis, dans “ Environmentally Friendly Syntheses Using Ionic Liquids “(2015), 31-66.

14. "Enhanced Two-Photon Fluorescence Imaging and Therapy of Cancer Cells via Gold@Bridged Silsesquioxane Nanoparticles", J. Croissant, M. Maynadier, O. Mongin, V. Hugues, M. Blanchard-Desce,* A. Chaix, X. Cattoën, M. Wong Chi Man, A. Gallud, M. Gary-Bobo,* M. Garcia, L. Raehm, J.-O. Durand,* Small, 2015, 11, 295-299. DOI : 10.1002/smll.201401759.

15. "Two-Photon “Caging” Groups : Effect of Position-Isomery on the Photorelease Properties of Aminoquinoline-Derived Photolabile Protecting Groups", C. Tran, T. Gallavardin, M. Petit, R. Slimi, H. Dhimane, M. Blanchard-Desce, F. C. Acher, D. Ogden, P. I. Dalko, Org. Lett., 2015, 17, 402-405. DOI : 10.1021/ol5035035.

16. "Fluorenyl porphyrins for combined two-photon excited fluorescence and photosensitization", O. Mongin, V. Hugues, M. Blanchard-Desce, A. Mehri, S. Drouet, D. Yao, C. Paul-Roth, Chem. Phys. Lett., 2015, 625, 151-156.

17. "Influence of the Synthetic Method on the Properties of Mesoporous Silica Nanoparticles Designed for Two-Photon Excitation", J. Croissant*, O. Mongin, V. Hugues, M. Blanchard-Desce*, X. Cattoën, M. Wong Chi Man, M. Maynadier, M. Garcia, M. Gary-Bobo, L. Raehm, J.-O. Durand*, J. Mater. Chem. B, 2015, 3, 5182-5188. DOI : 10.1039/c5tb00787a.

18. "Synthesis of Disulfide-Based Biodegradable Bridged Silsesquioxane Nanoparticles for Two-Photon Imaging and Therapy of Cancer Cells", J. G. Croissant, C. Mauriello-Jimenez, X. Cattoën, M. Wong Chi Man, L. Raehm, O. Mongin, M. Blanchard-Desce, M. Maynadier, M. Gary-Bobo, M. Garcia, P. Maillard, J.-O. Durand, Chem. Comm. 2015, 51, 12324-12327. DOI : 10.1039/c5cc03736k.

19. "Disulfide-Gated Mesoporous Silica Nanoparticles Designed for Two-Photon-Triggered Drug Release", J. G. Croissant, C. Qi, O. Mongin, V. Hugues, M. Blanchard-Desce, L. Raehm, X. Cattoën, M. Wong Chi Man, M. Maynadier, Gary-Bobo, M. Garcia, J. I. Zink, J.-O. Durand, J. Mater. Chem. B, 2015, 3, 6456-6461. DOI : 10.1039/C5TB00797F.

20. "Fluorescent phosphorus dendrimer as a spectral sensor for macrophage polarization and fate tracking in spinal cord injury", A. Shakhbazau, M. Mishra, T. Ho Chu, C. Brideau, K. Cummins, S. Tsutsui D. Shcharbin, S. Mignani, J.-P. Majoral, M. Blanchard-Desce, M. Bryszewska, V. W. Yong, P. Stys, J. van Minnen, Macromol. Biosci. 2015, DOI : 10.1002/mabi.201500150.

21. "A Cyclometallated Fluorenyl Ir(III) Complex as a Potential Sensitiser for Two-Photon Excited Photodynamic Therapy (2PE-PDT)", E. Boreham, L. Jones, A. Swinburne, M. Blanchard-Desce, V. Hugues, C. Terryn, F. Miomandre, G. Lemercier, L. S. Natrajana, Dalton Transactions, 2015, 44, 16127-16135. DOI : 10.1039/C5DT01855B.

22. "Identification of MRC2 and CD209 receptors as targets for photodynamic therapy of retinoblastoma using mesoporous silica nanoparticles", A. Gallud, D. Warther, M. Maynadier, M. Sefta, F. Poyer, C. D. Thomas, C. Rouxel, O. Mongin, M. Blanchard-Desce, A. Morère, L. Raehm, P. Maillard, J.-O. Durand, M. Garcia, M. Gary-Bobo, RSC Advances, 2015, 5, 75167-75172. DOI : 10.1039/c5ra14640b

23. Synthesis of Borinic Acids and Borinate Adducts Using Diisopropylaminoborane, L. Marciasini, Ludovic ; B Cacciuttolo, M.Vaultier, M.Pucheault, Org. Lett . 2015, 17, 3532-3535. DOI:10.1021/acs.orglett.5b01620

24. Amine-Borane Complexes : Air- and Moisture-Stable Partners for Palladium-Catalyzed Borylation of Aryl Bromides and Chlorides, H. D. S.Guerrand, M.Vaultier, S. Pinet,M. Pucheault, Advanced Synthesis & Catalysis, 2015, 357, 1167-1174. DOI:10.1002/adsc.201401153

25. "Dendritic molecular assemblies for singlet oxygen generation : meso-tetraphenylporphyrin-based biphotonic sensitizers with remarkable luminescence", D. Yao, V. Hugues, M. Blanchard-Desce, O. Mongin, C. O. Paul-Roth, F. Paul, New J. Chem., 2015, 39, 7730-7733.

26. "Two-photon absorption engineering of 5-(fluorenyl)-1,10-phenanthroline-based Ru(II) complexes", O. Mongin, M. Four, S. Chevreux, M. Blanchard-Desce, G. Lemercier, Chimia, 2015, 69, 666-669. DOI : 10.2533/chimia.2015.666.

27. "Differential Photoluminescent and Electrochemiluminescent Behavior for Resonance Energy Transfer Processes in Thermoresponsive Microgels", F. Pinaud, R. Millereux, P. Vialar-Trarieux, B. Catargi, S. Pinet, I. Gosse, N. Sojic and V. Ravaine, J. Phys. Chem. B, 2015, 119, 12954-12961.

28. "Selective, direct detection of acetylcholine in PBS solution, with self-assembled fluorescent nano-particles : experiment and modelling", L. Erieau-Peyrard, C. Coiffier, P. Bordat, D. Bégué, S. Chierici, S. Pinet, I. Gosse, I. Baraille, R. Brown, Phys. Chem. Chem. Phys., 2015, 17, 4168-4174.


1. Hyper-bright Near-Infrared Emitting Fluorescent Organic Nanoparticles for Single Particle Tracking, E. Genin, Z. Gao, J. A. Varela, J. Daniel, T. Bsaibess, I. Gosse, L. Groc, L. Cognet, M. Blanchard-Desce, Adv. Mater., 2014, 26, 2258–2261.Frontispiece paper.

2. A Green Approach for Producing Solvent-free Anisyl Acetate by Enzymecatalyzed Direct Esterification in Sponge-like Ionic Liquids Under Conventional and Microwave Heating, P. Lozano, J. M. Bernal, A. Lajarin, D. Romera, E. Garcia-Verdugo, G. Sanchez-Gomez, M. Pucheault, M. Vaultier, M. Isabel Burguete, S. V. Luis, Curr. Green Chem., 2014, 145-154.

3. Combined Transparency and Optical Nonlinearity Enhancement in Flexible Covalent Multimers by Operating Through-Space Interactions Between Dipolar Chromophores, V. Parthasarathy, R. Pandey, F. Terenziani, P. K. Das, M. Blanchard-Desce, Phys. Chem. Chem. Phys., 2014, 16, 9096-9103

4. Photo-Redox Activated Drug Delivery Systems Operating under Two-Photon Excitation in the Near-IR, T. M. Guardado-Alvarez, Lekshmi Sudha Devia, J.-M. Vabre, T. Pecorelli, B. J. Schwartz, J.-O. Durand, O. Mongin, M. Blanchard-Desce, J.I. Zink, Nanoscale, 2014, 6, 4652-4658.

5. Experimental and Theoretical Investigation of the First-order-Hyperpolarizability of Octupolar Merocyanines Dyes, F. Castet, M. Blanchard-Desce, F. Adamietz, Y. M. Poronik, D. T. Gryko, V. Rodriguez, Chem. Phys. Chem., 2014, 15, 2575–2581.

6. Non-classical, donor-acceptor-donor chromophores. A strategy for high two-photon brightness, A. I. Ciuciu, D. Firmansyah, V. Hugues, M. Blanchard-Desce, D. T. Gryko, L. Flamigni, J. Mater. Chem. C, 2014, 2, 4552-4565.

7. Two-photon induced fluorescence in novel π-expanded diketopyrrolopyrroles", M. Grzybowski, V. Hugues, M. Blanchard-Desce, D. T. Gryko*, Chem. Eur. J., 2014, 20, 1249-12501.

8. A new route towards fluorescent organic nanoparticles with red-shifted emission and increased colloidal stability, K. Amro, J. Daniel, G. Clermont, T. Bsaibess, M. Pucheault, E. Genin, M. Vaultier, M. Blanchard-Desce, Tetrahedron, 2014, 70, 1903-1909.

9. Ultra-Sensitive and Selective Hg2+ Chemosensor derived from substituted 8-Hydroxyquinoline Analogues, J. Bell, I. Samb, P.Y. Toullec, O. Mongin, M. Blanchard-Desce, V. Michelet, I. Leray, New. J. Chem., 2014, 38, 1072-1078

10. “Hyper-bright” molecular-based fluorescent nanoparticles made from polar chromophores for bioimaging purposes : a bottom-up approach", M. Blanchard-Desce, EPA Newsletter, Juin 2014, pp.27-32.

11. "Two-Photon Excitation of Porphyrin-Functionalized Porous Silicon Nanoparticles for Photodynamic Therapy", E. Secret, M. Maynadier, A. Gallud, A. Chaix, E. Bouffard, M. Gary-Bobo, N. Marcotte, O. Mongin , K. El Cheikh, V. Hugues, M. Auffan, C. Frochot, A. Morère, P. Maillard, M. Blanchard-Desce, M. J. Sailor, M. Garcia , J.-O. Durand, F. Cunin, Adv. Mater. 2014, 26, 7643-7648

12. "Mixed Periodic Mesoporous Organosilica Nanoparticles and Core-Shell Systems, Application to in Vitro Two-Photon Imaging, Therapy and Drug Delivery", J. Croissant, D. Salles, M. Maynadier, O. Mongin, V. Hugues, M. Blanchard-Desce,* X. Cattoën, M. Wong Chi Man, A. Gallud, M. Garcia, M. Gary-Bobo,* L. Raehm, J.-O. Durand,* Chem. Mater. 2014, 26, 7214-7220

13. Two-Photon-Triggered Drug Delivery via Fluorescent Nanovalves, J. Croissant, A. Chaix, O. Mongin, M. Wang, S. Clément, L. Raehm, J.-O. Durand, V. Hugues, M. Blanchard-Desce, M. Maynadier, A. Gallud, M. Gary-Bobo, M. Garcia, J. Lu, F. Tamanoi, D. P. Ferris, D. Tarn, J. I. Zink, Small, 2014, 10, 1752–1755

14. Borylation using group IV metallocene under mild conditions, L. D. Marciasini, M. Vaultier, M. Pucheault, Tetrahedron Lett., 2014, 1702–1705

15. Iron catalysis and water, a synergy for refunctionalisation of boron, J. L. Wood, L. D. Marciasini, M. Vaultier, M. Pucheault, Synlett, 2014, 25, 551-555.

16. Sequential dehydrogenation-arylation of diisopropylamine-borane complex catalyzed by Palladium nanoparticules H. D.S. Guerrand, L. D. Marciasini, T. Gendrineau, O. Pascu, S. Marre, S. Pinet, M. Vaultier, C. Aymonier, M. Pucheault, Tetrahedron, 2014,.

17. Comparison of homogeneous and heterogeneous Ga(III)-catalysis in the cycloisomerisation of 1,6-enynes K. Ben Hadj Hassen, K. Gaubert, M. Vaultier, M. Pucheault, S. Antoniotti, Green Chemistry Letters and Reviews, 2014, DOI:10.1080/17518253.2014.927534.

18. Borylation of Unactivated Aryl Chlorides under Mild Conditions by Using Diisopropylaminoborane as a Borylating Reagent H. D.S. Guerrand, L. D. Marciasini, M. Jousseaume, M. Vaultier, M. Pucheault, Chem. Eur. J., 2014, 5573–5579

19. Myofibrillar misalignment correlated to triad disappearance of mdx mouse gastrocnemius muscle probed by SHG microscopy, D. Rouède, P. Coumailleau, E. Schaub, J.-J. Bellanger, M. Blanchard-Desce, F. Tiaho, Biomedical Optics Express, 2014, 5, 858-875.


1. How to produce biodiesel easily using a green biocatalytic approach in sponge-like ionic liquids, P. Lozano, J. M. Bernal, G. Sanchez-Gomez, G. Lopez-Lopez, M. Vaultier, Energy & Environmental Science, 2013, 6, 1328-1338

2. Tandem triad systems based on FRET for two-photon induced release of glutamate, S. Picard, E.J. Cueto-Diaz, E. Genin, G. Clermont, F. Acher, D. Ogden, M. Blanchard-Desce, Chem. Commun., 2013, 49, 10805-10807.

3. Enforcing Luminescence at Organic Nanointerfaces : Luminescence Spatial Confinement and Amplification in Molecular-Based Core-Shell Nanoparticles, E. Campioli, C. Rouxel, M. Campanini, L. Nasi, M. Blanchard-Desce, F. Terenziani, Small, 2013, 9, 1982–1988

4. Two-Photon-Triggered Drug Delivery in Cancer Cells via Nanoimpellers, J. Croissant, M. Maynadier, A. Gallud, H. Peindy N’Dongo, J. L. Nyalosaso, G. Derrien, C. Charnay, J.-O. Durand, L. Raehm, F. Serein-Spirau, N. Cheminet, T. Jarrosson, O. Mongin, M. Blanchard-Desce, M. Gary-Bobo, M. Garcia, J. Lu, F. Tamanoi, D. Tarn, T. M. Guardado-Alvarez, J. I. Zink, Angew. Chem. Int. Ed., 2013, 125, 14058-14062

5. Two Photon Polarity Probes built from Octupolar Fluorophores : Synthesis, Structure-Properties Relationships and Use in Cellular Imaging, C. Le Droumaguet, A. Sourdon, E. Genin, O. Mongin, M. Blanchard-Desce, Chem. Asian J., 2013, 8, 2984-3001.

6. Bright, color-tunable fluorescent dyes based on imidazo[1,2-a]pyridines capable of two-photon absorption, D. Firmansyah, A. I. Ciuciu, V. Hugues, M. Blanchard-Desce, L. Flamigni, D. T. Gryko, Chem. Asian. J., 2013, 8, 1279-1294

7. Octupolar chimeric compounds built from quinoline caged acetate moieties. A novel approach for 2-photon uncaging of biomolecules, S. Picard, E. Genin, G. Clermont, V. Hugues, O. Mongin, M. Blanchard-Desce, New J. Chem., 2013, 37, 3899-3913.

8. Non-linear optical chemosensors for sodium ion based on rhodol chromophore, Y. M. Poronik, G. Clermont, M. Blanchard-Desce, D. T. Gryko, J. Org. Chem., 2013, 78, 11721–11732.

9. Continuous coflow synthesis of hybrid Palladium nanocrystals as catalysts for borylation reaction, O. Pascu, L. D. Marciasini, S. Marre, M. Vaultier, M. Pucheault, C. Aymonier, Nanoscale, 2013, 5, 12425-12431

10. V-shaped, strongly-emitting, π-expanded hydrophilic azacyanines – synthesis, linear and non-linear optical properties, M. Tasior, V. Hugues, M. Blanchard-Desce, D. T. Gryko, Asian J. Org. Chem., 2013, 2, 669–673

11. Strong enhancement of two-photon absorption properties in synergic “semi-disconnected” multiporphyrin assemblies designed for combined imaging and photodynamic therapy, O. Mongin, M. Sankar, M. Charlot, Y. Mir, M. Blanchard-Desce, Tet. Lett., 2013, 54, 6474–6478.

12. Mannose-functionalized porous silica coated magnetic nanoparticles for two-photon imaging or PDT of cancer cells, M. Perrier, M. Gary-Bobo, L. Lartigue, D. Brevet, A. Morère, M. Garcia, P. Maillard, L. Raehm, Y. Guari, J. Larionova, J.-O. Durand, O. Mongin, M. Blanchard-Desce, J. Nanoparticle Research, 2013, 15, 1602-1609

13. Iron-Catalysed Borylation of Arenediazonium Salts to Give Access to Arylboron Derivatives via aryl(amino)boranes at Room Temperature, L. D. Marciasini, N. Richy, M. Vaultier, M. Pucheault, Adv. Synth. Catal., 2013, 355, 1083–1088

14. Supercritical synthesis of biodiesel, J. M. Bernal, P. Lozano, E. Garcia-Verdugo, M. I. Burguete, G. Sanchez-Gomez, G. Lopez-Lopez, M. Pucheault, M. Vaultier, S. V. Luis, Molecules, 2012, 17, 8696-8719

15. Functionalized nanoparticles for drug delivery, one- and two-photon photodynamic therapy as a promising treatment of retinoblastoma, A. Gallud, A. Da Silva, M. Maynadier, I. Basile, S. Fontanel, C. Lemaire, P. Maillard, M. Blanchard-Desce, O. Mongin, A. Morère, J.-O. Durand, L. Rhaem, M. Garcia, M. Gary-Bobo, J. Clin. Exp. Ophthalmol., 2013, 4, 255-288

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