Theme I : Photocatalysis and Homogeneous Catalysis


Organic catalysis and catalytic processes combining organometallic catalysis and activation by light are fields which are experiencing very significant growth. In these fields our objectives are to develop catalytic systems of practical interest and to understand the reaction mechanisms involved.

Photolatent/Photoredox Cu catalysis

  • generating low valent metallic species by photoinduced electron transfer
  • photoreducible copper catalysts for click chemistry in organic solvents and water – homogeneous or recyclable heterogeneous, supported on chitosan
  • functionalization of alkenes : allylic trifluoromethylations with a catalytic load 100 to 200 times lower than that of the known systems
  • dual organic photoredox / Cu catalysis for the direct functionalization of C (sp3) –H bonds via a Giese type reaction (Coll. P. Toullec – GSH – ISM)

Organic photocatalysis

  • iodoperfluoroalkylations of alkenes and alkynes by of combination of benzophenone, UVAs and methanol
  • iodotrifluoromethylations of alkenes using Togni’s reagent as a source of CF3 or iodine, exploiting the reducing power of alpha-hydroxyisopropyl radicals
  • functionalization by nucleophiles (alcohols, thiols) of C-H alpha bonds of cyclic ethers by combining BP, UVAs and N-fluorobenzenesulfonimide as oxidant
  • appearance of the "taste of light" in white wines and Champagnes

JPEG - 183.5 ko

Homogeneous Au and Ag catalysis

  • homogeneous gold and silver catalysis leads to a wide variety of complex molecules, thanks to the Lewis acid and redox properties of these transition metals.
  • catalysis in tandem addition / cycloisomerization reactions of alkynes using original thioether ligands, aliphatic or carried by a 9,10-diphenylanthracene, coordinating silver (I) (stoichiometries M2L, M2L2, M6L4)
  • alkyne activation, single and one-pot reactions combining two successive cyclizations, exploiting Au(I) generated by photoreduction of AuCl3 / thioether ligand complexes

JPEG - 478.4 ko

H-bond based catalysis

  • gentle and selective activation of C = O and C – F bonds by organocatalysis exploiting hydrogen bonds
  • moderate to strong activity in the polymerization reaction by gentle and selective opening of lactones (C = O) using phosphazenium and azaphosphatranium ionic catalysts
  • activation of the stable C – F bond using thioureas with a 1-trifluoromethyl-ethanol group, to efficiently catalyzing a nucleophilic substitution of benzyl fluoride by amines

JPEG - 375.3 ko

Links to publications :

personal page of Jean-Marc Vincent

personal page of Brigitte Bibal

personal page of Dominique Lastécouères

personal page of Dario Bassani





Actualités

Publication d’un article VIP dans Angewandte Chemie - Collab. Groupes ORGA-SQ /THEO (Juin.2021)
14 juin

Une synthèse bioinspirée et efficace d’une substance naturelle (...)


Mireille Blanchard Desce – Groupe IPM : article accepté dans la revue Advanced Materials
4 mai

Les résultats à la fois impressionnants et inattendus sont issus (...)


Prix d’instrumentation de la division de chimie physique 2020
8 avril

Lauréats : D. Talaga (Ingénieur de recherche CNRS) et S. Bonhommeau (...)