Asymmetric total synthesis of naturals products using radicals, organocatalysis and organometallic chemistry

Group Leader :
Prof. Yannick LANDAIS

For more informations, visit the group website :

Key words :
organic chemistry, asymmetric synthesis, alkaloids, natural products, silicon (silyl radicals, silylium ions...), radical cascades, desymmetrization, organocatalysis, organometallics

Recent Publications :

> “Total Synthesis of (+/-)-Eucophylline. A Free-radical Approach to the Synthesis of the Azabicyclo[3.3.1]nonane Skeleton.”
H. Hassan, S. Mohammed, F. Robert, Y. Landais, Org. Lett. 2015, 21, 4518-4521.

>“Chiral Memory in Silylium Ions.”
P. Ducos, V. Liautard, F. Robert, Y. Landais, Chem. Eur. J. 2015, 21, 11573–11578.

>“From the N-Heterocyclic Carbene-Catalyzed Conjugate Addition of Alcohols to the Controlled Polymerization of (Meth)acrylates.”
W. Nzahou Ottou, D. Bourichon, J. Vignolle, A.-L. Wirotius, F. Robert, Y. Landais, J.-M. Sotiropoulos, K. Miqueu, D. Taton, Chem. Eur. J. 2015, 21, 9447–9453.

>“Synthesis of New Sulfonyloximes and Their Use in Free-Radical Olefin Carbo-oximation.”
B. Ovadia, F. Robert, Y. Landais, Org. Lett. 2015, 17, 1958-1961.

>“Base-catalyzed Intramolecular Hydroamination of 1-Substituted Cyclohexa-2,5-dienes. Rationalization of the Mechanism and Application to the Total Synthesis of (+)-epi-Elwesine.”
R. Lebeuf, G. Rousseau, K. Schenk, F. Castet, F. Robert, Y. Landais Chem. Eur. J. 2014, 20, 14771–14782.

>“Synthesis of the C10-C24-Bis-spiroacetal Core of 13-Desmethyl Spirolide C, Based on a sila-Stetter-acetalization Process.”
J. Labarre-Lainé, I. Periñan, V. Desvergnes, Y. Landais Chem. Eur. J. 2014, 20, 9336-9341.

Group members :

Permanent Staff
> Pr. LANDAIS Yannick
> Dr. ROBERT Frédéric

> 7 PhD students, 2 post-docs, 1 ERASMUS student, 1 visiting PhD student.

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