Dr Emilie GENIN
Associate Professor, Univ. Bordeaux
Molecular and Material Chemistry group - C2M

Email : emilie.genin@u-bordeaux.fr

ISM, UMR 5255 CNRS
Bat A12, RDC Est
CS 10004
33405 Talence Cedex, FRANCE

Phone : +33 (0)5 40 00 29 93

RESEARCH INTERESTS

Keywords : multistep organic synthesis, functionalization of (nano)materials and surfaces, fluorescent molecules and materials, chemistry-biology.

The immobilization of biomolecules on solid substrates using Self-Assembled Monolayers (SAMs) attracts a lot of attention in the very active research field of bio-nanotechnologies and advanced functional materials, for many applications such as biosensors, cell adhesion and tissue engineering, medical implants. Projects currently in progress focus on the multi-step organic synthesis of new dual-end functional silanes. They will be used for the elaboration of new SAMs on silica surfaces thanks to strong hydrogen bonds interactions. These smart nanofilms will enable the selective ligation of biomolecules and concomitantly the direct follow-up of the process. Targeted biological applications are related to the challenging field of cell proliferation and regenerative medicine. Research projects are highly interdisciplinary, being at the interface between organic chemistry, (nano)materials and biology.

EDUCATION AND PROFESSIONAL EXPERIENCE

2019 : Habilitation à Diriger des Recherches, Univ. Bordeaux, France
2011- : Associate Professor, Univ. Bordeaux, ISM UMR 5255, France
2007-2011 : Associate Professor, University of Rennes 1, CPM UMR 6510, France
2006-2007 : Postdoctoral associate, CEA Saclay, France (Dr C. Mioskowski, Dr E. Doris)
2003-2006 : Ph D in Organic Chemistry (ENSCP, Paris VI University, France) under the supervision of : Pr J.-P. Genêt and Dr V. Michelet (ENSCP Paris)
2000-2004 : Ecole Normale Supérieure (Paris, France)
2003 : Agrégation de sciences physiques option chimie
2002 : Multinational Master of molecular chemistry in Ecole polytechnique

DISTINCTIONS

2017 : The “Prime d’Encadrement Doctoral et de Recherche (PEDR)”
2008 : The medal of the city of Rennes
2007 : The Sigma-Aldrich-Fluka-SFC 2007 PhD prize awarded by the Organic Chemistry Division of the French Chemical Society.

ADMINISTRATIVE AND SCIENTIFIC RESPONSIBILITIES

2019- : Member of the council for the SMR Department of Bordeaux University
2018 : Jury member of the PhD defense of A. Hamoud
2018 : Member of the committee examining promotions for Bordeaux ST
2017 : Member of a recruitment committee for an assistant professor position(UPMC)
2017 : Jury member of the PhD defense of Y. Mousli
2017-  : elected member of the council “Collège Sciences et Technologie” of Bordeaux University
2017 : Co-organization of the congress “2ièmes journées plénières du GDR B2I”
2016- : member of the council in charge of scientific communication management
2015- : nominated member of CNU, section 32
2014 : Co-organization of the “TOPBIO Conference”
2012- : jury member of Agrégation de Physiques
2011- : member of the council of the ISM
2012-2014 : member of the council in charge of scientific communication management
2009 : member of a recruitment committee for an assistant professor position (UR1-pharmacy)
2007-2011 : Elected member of the laboratory council of UMR 6510
Communication correspondent of UMR 6510
Scientific Diffusion correspondent of UMR 6510 : Coordination and co-organization of scientific dissemination activities for schoolkids (Fête de la science and Festival des Sciences in 2007 and 2008)
2006 : Co-organization of a congress in organic chemistry (RCO 2006, 1 day, 130 participants)
2003-2005 : Delegate of the PhD students to Pr Genêt’s Laboratory staff meetings

CONFERENCES AND COMMUNICATIONS

3 international and national invited conferences
Course on “Chemistry in water” at C2P2I thematic school (2010, Roscoff, france)
Course on Nanomedicine for undergraduate students at Montaigne high school (2018, Bordeaux)
22 oral communications (including 13 presented personally)
over 30 poster communications

TEACHING ACTIVITIES

2012-  : Associate Professor - Univ. Bordeaux
Course of “heterocyclic chemistry” for Master 2 including its elaboration ; Course of “organometallic chemistry” for Master 1 including its elaboration ; tutorial classes and practical work in organic chemistry (ENSCBP school, Licence)
2007- 2012 : Associate Professor - University of Rennes 1
Courses, supervised practical work and laboratory training in organic, organometallic and general chemistry (Licence, Master, Agrégation, CAPES).
2005-2006 : “Colles” (Oral exams) in lycée Hoche in CPGE (physics and chemistry) laboratory training for the Olympiads of Chemistry
2004-2006  : Teaching assistant in Ecole Nationale Supérieure de Chimie de Paris – supervised practical work and laboratory training in spectroscopy for first year students (licence).
2001-2002 : “Colles” (Oral exams) in lycée Hoche in CPGE (physics and chemistry)

PUBLICATIONS

42. « Hydrosilylation of azide-containing olefins as a convenient access to azidoorganotri-alkoxysilanes for self-assembled monolayer elaboration onto silica by spin coating » Y. Mousli, L. Rouvière, I. Traboulsi, J. Hunel, T. Buffeteau, K. Heuzé, L. Vellutini, E. Genin ChemistrySelect 2018, 3, 7333-7339

41. « Structure-based design of human immuno- and constitutive proteasomes inhibitors » N. Richy, D. Sarraf, X. Maréchal, N. Janmamode, R. Le Guével, E. Genin, M. Reboud-Ravaux, J. Vidal Eur. J. Med. Chem. 2018, 145, 570-587

40. « Fluorescent Periodic Mesoporous Organosilica Nanoparticles Dual-Functionalized via Click Chemistry for Two-Photon Photodynamic Therapy in Cells » J.G. Croissant, S. Picard, D. Aggad, M. Maynadier, O. Mongin, G. Clermont, C. Mauriello Jimenez, M. Klausen, E. Genin, X. Cattoën, M. Wong Chi Man, L. Raehm, M. Garcia, M. Gary-Bobo, M. Blanchard-Desce, J.-O. Durand J. Mater. Chem. B., 2016, 4, 5567-5574

39. « Cooperative veratryle and nitroindoline cages for two-photon uncaging in the NIR » E.J. Cueto Diaz, S. Picard, V. Hugues, E. Genin, M. Blanchard-Desce Chem. Eur. J., 2016, 22, 10848–10859. (inside cover picture)

38. « Nanoparticles restore lysosomal acidification defects : Implications for Parkinson and other lysosomal-related diseases » M. Bourdenx, J. Daniel, E. Genin, F.N. Soria, M. Blanchard-Desce, E. Bezard, B. Dehay Autophagy, 2016, 12, 472-483.

37. « Water as solvent and solvent-free reactions » E. Genin, V. Michelet Green Process Engineering From Concepts to Industrial Applications , edited by M. Poux, P. Cognet, C. Gourdon. CRC Press 2015. (book chapter)

36. « 8-Br-quinoline derivatives as sensitizers combining two-photon induced fluorescence and singlet oxygen generation » S. Picard, G. Clermont, E. Genin, M. Blanchard-Desce Tetrahedron, 2015, 71, 1088–1094.

35. « Cooperative Dyads for Two-Photon Uncaging » E.J. Cueto-Diaz, S. Picard, V. Chevasson, J. Daniel, V. Hugues, O. Mongin, E. Genin, M. Blanchard-Desce Org. Lett. 2015, 17, 102−105.

34. « Noncovalent Fluorescent Probes of Human Immuno- and Constitutive Proteasomes » A. Desvergne, Y. Cheng, S. Grosay-Gaudrel, X. Maréchal, M. Reboud-Ravaux, E. Genin, J. Vidal J. Med. Chem. 2014, 57, 9211-9217.

33. « Gold-catalyzed addition of HX to alkynes » E. Genin, V. Michelet, 2014, in Patai’s Chemistry of Functional Groups, edited by I. Marek. John Wiley & Sons, Ltd : Chichester, UK. DOI : 10.1002/9780470682531.PAT0814. Published online 6/22/2014 (book chapter)

32. « A New Route towards Fluorescent Organic Nanoparticles with Red-shifted Emission and Increased Colloidal Stability » K. Amro, J. Daniel, G. Clermont, T. Bsaibess, M. Pucheault, E. Genin, M. Vaultier, M. Blanchard-Desce Tetrahedron, 2014, 70, 1903-1909.

31. « Hyper-bright Near-Infrared Emitting Fluorescent Organic Nanoparticles for Single Particle Tracking » E. Genin, Z. Gao, J. A. Varela, J. Daniel, T. Bsaibess, I. Gosse, L. Groc, L. Cognet, M. Blanchard-Desce Adv. Mater., 2014, 26, 2258-2261.

30. « Tandem triad systems based on FRET for two-photon induced release of glutamate » S. Picard, E.J. Cueto-Diaz, E. Genin, G. Clermont, F. Acher, D. Ogden, M. Blanchard-Desce Chem. Commun., 2013, 49, 10805-10807.

29. « Octupolar chimeric compounds built from quinoline caged acetate moieties. A novel approach for 2-photon uncaging of biomolecules » S. Picard, E. Genin, G. Clermont, V. Hugues, O. Mongin, M. Blanchard-Desce New J. Chem. 2013, 37, 3899-3913.

28. « Two Photon Polarity Probes built from Octupolar Fluorophores : Synthesis, Structure-Properties Relationships and Use in Cellular Imaging » C. Le Droumaguet, A. Sourdon, E. Genin, O. Mongin, M. Blanchard-Desce Chem. Asian J. 2013, 8, 2984-3001.

27. « Dimerized Linear Mimics of Natural Cyclopeptide (TMC-95A) Are Potent Noncovalent Inhibitors of the Eukaryotic 20S Proteasome » A. Desvergne, E. Genin, X. Maréchal, N. Gallastegui, L. Dufau, N. Richy, M. Groll, J. Vidal, M. Reboud-Ravaux J. Med. Chem. 2013, 56, 3367-3378.

26. « 1,2,4-Oxadiazoles Identified by Virtual Screening and their Non-covalent Inhibition of the Human 20S Proteasome » X. Maréchal, E. Genin, L. Qin, O. Sperandio, M. Montes, N. Basse, N. Richy, M.A. Miteva, M. Reboud-Ravaux, J. Vidal, B.O. Villoutreix Current Med Chem 2013, 20, 2351-2362.

25. « Fluorescence and two-photon absorption of push–pull aryl(bi)thiophenes : structure–property relationships » E. Genin, V. Hugues, G. Clermont, C. Herbivo, M.C.R. Castro, A. Comel, M.M.M. Raposo, M. Blanchard-Desce Photochem. Photobiol. Sci. 2012, 11, 1756-1766.

24. « Noncovalent inhibition of 20S proteasome by pegylated dimerized inhibitors » X. Maréchal, A. Pujol, N. Richy, E. Genin, N. Basse, M. Reboud-Ravaux, J. Vidal Eur. J. Med. Chem. 2012, 52, 322-327.

23. « 20S Proteasome Inhibition : Designing New Non-Covalent Linear Peptide Mimics of the Natural Product TMC-95A » M. Groll, N. Gallastegui, X. Maréchal, V. Le Ravalec, N. Basse, N. Richy, E. Genin, R. Huber, L. Moroder, J. Vidal, M. Reboud-Ravaux ChemMedChem 2010, 5, 1701-1705.

22. « l’eau comme solvant et réactions sans solvant » E. Genin, L. Leseurre, V. Michelet. Génie des procédés durables Dunod 2010. (book chapter)

21. « Novel Organic Proteasome Inhibitors Identified by Virtual and in Vitro Screening » N. Basse, M. Montes, X. Maréchal, L. Qin, M. Bouvier-Durand, E. Genin, J. Vidal, B. O. Villoutreix, M. Reboud-Ravaux J. Med. Chem. 2010, 53, 509-513.

20. « Proteasome Inhibitors : Recent Advances and New Perspectives in Medicinal Chemistry » E. Genin, M. Reboud-Ravaux, J. Vidal Curr. Top. Med. Chem. 2010, 10, 232-256. (review)

19. « Synthesis of functionalized carbo- and heterocycles via gold-catalyzed cycloisomerization reactions of enynes » L. Leseurre, C.-M. Chao, T. Seki, E. Genin, P.Y. Toullec, J.-P. Genêt, V. Michelet Tetrahedron 2009, 65, 1911-1918.

18. « Towards asymmetric Au-catalyzed hydroxy- and alkoxycyclization of 1,6-enynes » C.-M. Chao, E. Genin, P.Y. Toullec, J.-P. Genêt, V. Michelet J. Organomet. Chem. 2009, 694, 538-545.

17. « CrAsH-Quantum Dot Nanohybrids for Smart Targeting of Proteins » E. Genin, O. Carion, B. Mahler, B. Dubertret, N. Arhel, P. Charneau, E. Doris, C. Mioskowski J. Am. Chem. Soc. 2008, 130, 8596-8597.

16. « Au2O3 as a Stable and Efficient Catalyst for the Selective Cycloisomerization of gamma-Acetylenic Carboxylic Acids to gamma-Alkylidene gamma-Butyrolactones » P. Y. Toullec, E. Genin, S. Antoniotti, J.-P. Genêt, V. Michelet Synlett 2008, 707-711.

15. « Heterogeneous hydrogenation of bicyclo[2.2.2]octenes on Rh/TPPTS/LDH catalysts » F. Iosif, V. I. Parvulescu, M. E. Pérez-Bernal, R. J. Ruano-Casero, V. Rives, K. Kranjc, S. Polanc, M. Kočevar, E. Genin, J.-P. Genêt, V. Michelet J. Mol. Catal. A : Chem. 2007, 276, 34-40.

14. « Gold-Catalyzed Hydroxy- and Alkoxycyclization of Functionalized Enynes » E. Genin, L. Leseurre, P.Y. Toullec, J.-P. Genêt, V. Michelet Synlett 2007, 1780-1784.

13. « Pd0-Catalyzed Allylic Aminations : Kinetics and Mechanism of the Reaction of Secondary Amines with Cationic [(η3-allyl)PdL2]+ Complexes » C. Amatore, E. Genin, A. Jutand, L. Mensah Organometallics 2007, 26, 1875-1880.

12. « Gold catalysis in organic synthesis : efficient intramolecular cyclization of γ-acetylenic carboxylic acids to 5-exo-alkylidene-butyrolactones » E. Genin, P.Y. Toullec, P. Marie, S. Antoniotti, C. Brancour, J.-P. Genêt, V. Michelet ARKIVOC 2007, 5, 67-78.

11. « Room-Temperature AuI-Catalyzed C-C Bond Formation through a Tandem Friedel–Crafts-Type Addition/Carbocyclization Reaction » P.Y. Toullec, E. Genin, L. Leseurre, J.-P. Genêt, V. Michelet Angew. Chem. Int. Ed. 2006, 45, 7427-7430. Angew. Chem. 2006, 118, 7587-7590.

10. « Water-Soluble Triphenylphosphane-3,3’,3’’-tricarboxylate (m-TPPTC) Ligand and Methylated Cyclodextrins : A New Combination for Biphasic Rhodium-Catalyzed Hydroformylation of Higher Olefins » S. Tilloy, E. Genin, F. Hapiot, D. Landy, S. Fourmentin, J.-P. Genêt, V. Michelet, E. Monflier Adv. Synth. Catal. 2006, 348, 1547-1552.

9. « Efficient and Green Access to Functionalized and Highly Constrained Heteropolycyclic Derivatives via a Microwave-Accelerated Diels-Alder Cycloaddition and Heterogeneous Hydrogenation Sequence » K. Kranjc, M. Kočevar, F. Iosif, S. M. Coman, V. I. Parvulescu, E. Genin, J.-P. Genêt, V. Michelet Synlett 2006, 1075-1079.

8. « Room Temperature Au(I)-Catalyzed exo-Selective Cycloisomerization of Acetylenic Acids : An Entry to Functionalized gamma-Lactones » E. Genin, P.-Y. Toullec, S. Antoniotti, C. Brancour, J.-P. Genêt, V. Michelet J. Am. Chem. Soc. 2006, 128, 3112-3113.

7. « Highly Efficient Access to Strained Bicyclic Ketals via Gold-Catalyzed Cycloisomerization of Bis-homopropargylic Diols » S. Antoniotti, E. Genin, V. Michelet, J.-P. Genêt J. Am. Chem. Soc. 2005, 127, 9976-9977.

6. « An IrI-Catalyzed exo-selective Tandem Cycloisomerization / Hydroalkoxylation of Bis-homopropargylic Alcohols at Room Temperature » E. Genin, S. Antoniotti, V. Michelet, J.-P. Genêt Angew. Chem. Int. Ed. 2005, 44, 4949-4953. Angew. Chem.. 2005, 117, 5029-5033.

5. « A Novel Water-soluble m-TPPTC Ligand : Steric and Electronic Features – Recent Developments in Pd- and Rh-Catalyzed C-C Bond Formations » E. Genin, R. Amengual, V. Michelet, M. Savignac, A. Jutand, L. Neuville, J.-P. Genêt Adv. Synth. Catal. 2004, 346, 1733-1741.

4. « Rh-catalyzed addition of boronic acids to alkynes for the synthesis of trisubstituted alkenes in a biphasic system - Mechanistic study and recycling of the Rh/m-TPPTC catalyst » E. Genin, V. Michelet, J.-P. Genêt J. Organomet. Chem. 2004, 689, 3820-3830.

3. « Efficient synthesis of trisubstituted alkenes in an aqueous-organic system using a versatile and recyclable Rh/m-TPPTC catalyst » E. Genin, V. Michelet, J.-P. Genêt Tetrahedron Lett. 2004, 45, 4157-4161.

2. « Structural and kinetic effects of chloride ions in the palladium-catalyzed allylic substitutions » T. Cantat, E. Genin, C. Giroud, G. Meyer, A. Jutand J. Organomet. Chem. 2003, 687, 365-376.

1. « Convenient Synthesis of New Anionic Water-Soluble Phosphanes and Applications in Inter- and Intramolecular Heck Reactions » R. Amengual, E. Genin, V. Michelet, M. Savignac, J.-P. Genêt Adv. Synth. Catal. 2002, 344, 393-398.