Organic synthesis and natural products (ORGA)

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Group presentation

"Organic synthesis and natural products" group focuses mostly on developping new methods for organic synthesis. These methods are applied to natural products total synthesis and to organic and organometallic catalytic systems. Applications are then related to the pharmaceutical industry, fine chemicals, agrochemistry, cosmetics, food chemistry and polymer sciences.

Research activity

Research is organized around 3 different teams:
> Asymmetric total synthesis of naturals products using radicals, organocatalysis and organometallic chemistry (Pr LANDAIS)
> Sustainable Organic Synthesis : Boron chemsitry, Catalysis and Microfluidics (Dr PUCHEAULT)
> Synthesis and mode of action of naturals products having biological interests (Pr QUIDEAU)


Organic synthesis, bioactives natural products, asymmetric synthesis, labeled radiotracers, imagery, palladium couplings, tannins and polyphenol chemistry, hypervalent iodine, peptidomimetics, alkaloids, silicon, radical cascades, organocatalysis, boron, millifluidics, nanocatalysis.

Group members

> Dr. CHABAUD Laurent (CNRS Researcher)
> CORNU Anaëlle (Technician)
> Dr. DEFFIEUX Denis (Assistant Professor)
> Prof. LANDAIS Yannick (Professor)
> LUSSEAU Jonathan (Technician)
> Dr. PEIXOTO Philippe (CNRS Researcher)
> Dr. PINET Sandra (Assistant Professor)
> Prof. POUYSEGU Laurent (Professeur)
> Dr. PUCHEAULT Mathieu (CNRS Research Director)
> Prof. QUIDEAU Stéphane (Professeur)
> QUINAUX-OTTAVIANI Magali (Technician)
> Dr. ROBERT Frédéric(CNRS Researcher))

Recent publications

  • Total Synthesis of (+/-)-Eucophylline. A Free-radical Approach to the Synthesis of the Azabicyclo[3.3.1]nonane Skeleton.
    H. Hassan, S. Mohammed, F. Robert, Y. Landais, Org. Lett. 2015, 17, 4518-4521. link
  • Chiral Memory in Silylium Ions.
    P. Ducos, V. Liautard, F. Robert, Y. Landais, Chem. Eur. J. 2015, 21, 11573–11578. link
  • Synthesis of New Sulfonyloximes and Their Use in Free-Radical Olefin Carbo-oximation.
    B. Ovadia, F. Robert, Y. Landais, Org. Lett. 2015, 17, 1958-1961. link
  • Gallotannins and Tannic Acid: First Chemical Syntheses and In Vitro Inhibitory Activity on Alzheimer’s Amyloid b-Peptide Aggregation
    Sylla, T.; Pouységu, L.; Da Costa, G.; Deffieux, D.; Monti, J.-P.; Quideau, S. . Angew. Chem. Int. Ed. 2015, 54, 8217-8221. link
  • Asymmetric Hydroxylative Phenol Dearomatization Promoted by Chiral Binaphthylic and Biphenylic Iodanes.
    Bosset, C.; Coffinier, R.; Peixoto, P. A.; El Assal, M.; Miqueu, K.; Sotiropoulos, J.-M.; Pouységu, L.; Quideau, S. Angew. Chem. Int. Ed. 2014, 53, 9860-9864. link
  • New Affinity-Based Probes for Capture of Flavonoid-Binding Proteins.
    Carrié, H.; Tran, D. T.; Rousseau, S.; Chaignepain, S.; Schmitter, J.-M.; Deffieux, D.; Quideau, S. Chem. Commun. 2014, 50, 9387-9389. link
  • Synthesis of borinic acids and borinate adducts using diisopropylaminoborane
    L. Marciasini, B. Cacciuttolo, M. Vaultier, M. Pucheault Org Lett., 2015, 17, 3532-3535. link
  • Simple metal salts supported on montmorillonite as recyclable catalysts for intramolecular hydroalkoxylation of double bonds in conventional and VOC-exempt solvents
    I. Notar Francesco, B. Cacciuttolo, M. Pucheault and S. Antoniotti Green Chem., 2015, 17, 837-841. link
  • Amine–Borane Complexes: Air- and Moisture-Stable Partners for Palladium-Catalyzed Borylation of Aryl Bromides and Chlorides
    H. D. S. Guerrand, M. Vaultier, S. Pinet and M. Pucheault Adv. Synth. Catal., 2015, 6, 1167-1174. link.


Mailing Address :

Team Landais

ISM, Building A12
1st floor West

351 cours de la libération
33405 Talence cedex

Team Pucheault

ground floor

2 Rue Robert Escarpit
33600 Pessac

Team Quideau

ISM, Building A12
ground floor

351 cours de la libération
33405 Talence cedex

Sustainable Organic Synthesis : Boron chemistry, Catalysis and Microfluidics

Activities of the team are concentrated on three main topics : boron chemistry, catalysts design and use, and development of fluidic technical solutions for problems in organic synthesis. Please go check our Group Website

Asymmetric total synthesis of naturals products using radicals, organocatalysis and organometallic chemistry

Group Leader: Prof. Yannick LANDAIS For more informations, visit the group website: Key words: organic chemistry, asymmetric synthesis, alkaloids, natural products, silicon (silyl radicals, silylium ions...), radical cascades, desymmetrization, (...)

Synthesis and mode of action of naturals products having biological interests

For more informations, Visit our group website:


La synthèse organique bordelaise à l’honneur !
18 December 2017

Stéphane Quideau est le lauréat 2017 du prix de la Division de (...)

Publication d’un article dans Nature Chemistry - Groupe COMEX
31 May 2018

Des chercheurs du groupe COMEX ont mis en évidence le comportement (...)

Stéphane Quideau nommé Membre Senior de l’IUF
13 November 2019

Le Professeur Stéphane Quideau (ISM/groupe ORGA) a été nommé Membre (...)