Analytical NanoSystems (NSysA)

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Group presentation

Our group is located at the National Engineering School of Chemistry, Biology and Physics (ENSCBP). The main activities are focused on the development of new analytical tools and techniques with a special accent on miniaturized systems applied to the study of biological systems and biomedical issues. Our research addresses problems resulting from the ever increasing demands of our modern society concerning various aspects like public health, security and environmental issues. In order to tackle these problems, the discipline of Analytical Chemistry has to evolve constantly and improve its performance.

Distinguishing molecules with almost identical physico-chemical properties, tracking their evolution with a high spatio-temporal resolution, detecting them at the cell or subcellular level in complex environments, are some of the challenges that we work on. With this respect current projects include biofunctionalized nanoparticles, chemical sensors for biology, electrochemistry of biosystems, micro/nanoscale imaging and smart functional nanostructures. In order to work successfully on these topics we have combined in our group an interdisciplinary team with know-how ranging from electrochemistry and optics to organic or colloidal synthesis and cell biology. The resulting synergy is the guaranty for original systems dedicated to contribute to the solution of some of the current problems in the field of Analytical Chemistry.

Research activity

> Chemical sensors for biology (molecular probes for detection of bio-relevant species, electrochemical biosensors).
> Micro/nanoscale imaging (optical tools for imaging & enhanced coupled methodologies, electrochemical imaging).
> Smart functional nanostructures (micro/nanogels for drug delivery, nanostructured electrodes, functional inorganic particles).
> Electrochemistry of biosytems (cell & sub-cellular analysis, protein/peptide electrochemistry, electron transfer in DNA).

Key Words

Electrochemistry, biochemistry, inorganic and organic synthesis, soft matter, colloids, optics, spectroscopy, micro/nanomaterials, chemical sensors, biosensors, supramolecular chemistry, fluorescence, electrochemiluminescence, neurotransmitters, electrochemical imaging, microgels, drug delivery, stimuli-responsive polymers, glucose, porous electrodes, Janus particles, bipolar electrochemistry, single cell electrochemistry, reactive oxygen and nitrogen species, mitochondria, DNA, peptides.

Group members

Dr. Valérie Ravaine (INP Professor & Group Leader)
Mrs. Cécile Alliaire (INP Administrator)
Dr. Stéphane Arbault (CNRS Research Director)
Dr. Laurent Bouffier (CNRS Researcher)
Mr. Patrick Garrigue (INP Engineer)
Dr. Bertrand Goudeau (CNRS Assistant Engineer)
Pr. Alexander Kuhn (INP Professor)
Mrs. Véronique Lapeyre (UB Assistant Engineer)
Dr. Adeline Perro-Marre (IPB Assistant Professor)
Mrs. Aline Simon-Lalande (INP Administrator)
Pr. Neso Sojic (INB Professor)
Dr. Dodzi Zigah (UB Assistant Professor)

Brivatech: Technology Transfer

Dr. Stéphane Reculusa (ADERA Engineer)

Recent publications

Des biopiles enzymatiques pour alimenter des circuits électroniques implantables
E. Suraniti, A.G. Mark, J. Roche, H. Richter, A. Kuhn, P. Fischer, N. Mano
L’Actualité Chimique 2018, 427-428,127-128

Une façon inhabituelle de briser la symétrie moléculaire: les métaux mesoporeux chiraux
A. Kuhn
L’Actualité Chimique 2018, 426,19-24

Gateway state-mediated, long-range tunnelling in molecular wires
S. Sangtarash, A. Vezzoli, H. Sadeghi, N. Ferri, H. M. O’Brien, I. Grace, L. Bouffier, S. J. Higgins, R. J. Nichols, C. J. Lambert
Nanoscale 2018, DOI: 10.1039/C7NR07243K

Tuning Electrochemiluminescence in Multi-Stimuli Responsive Hydrogel Films
Haidong Li, Silvia Voci, Valérie Ravaine and Neso Sojic
J. Phys. Chem. Lett., 2018, 9, 340–345

Bipolar Conducting Polymer Crawlers Based on Triple Symmetry Breaking
B. Gupta, B. Goudeau, P. Garrigue, A. Kuhn
Adv. Funct. Mater. 2018, 1705825

Organization of Microgels at the Air−Water Interface under Compression: Role of Electrostatics and Cross-Linking Density
C. Picard, P. Garrigue, M.C. Tatry, V. Lapeyre, S. Ravaine, V. Schmitt, V. Ravaine
Langmuir, 2017, 33, 7968-7981

Pulsed electroconversion for highly selective enantiomer synthesis
C. Wattanakit, T. Yutthalekha, S. Asssavapanumat, V. Lapeyre, A. Kuhn
Nature Comm. 2017, 8, 2087

Single Cell Electrochemiluminescence Imaging: From the Proof-of-Concept to Disposable Device-Based Analysis
Giovanni Valenti, Sabina Scarabino, Bertrand Goudeau, Andreas Lesch, Milica Jovic, Elena Villani, Milica Sentic, Stefania Rapino, Stephane Arbault, Francesco Paolucci, and Neso Sojic
J. Am. Chem. Soc., 2017,DOI: 10.1021/jacs.7b09260

Wireless Light Emitting Electrochemical Rotors
V. Eßmann, S. Voci, G. Loget, N. Sojic, W. Schuhmann, A. Kuhn
J. Phys. Chem. Lett. 2017,8, 4930–4934

Core–shell colloidal particles with dynamically tunable scattering properties
Guangnan Meng, Vinothan N. Manoharan and Adeline Perro
Soft Matter, 2017,13, 6293-6296

Bipolar Electrode Array Embedded in a Polymer Light-Emitting Electrochemical Cell
J. Gao, S. Chen, F. AlTal, S. Hu, L. Bouffier, G. Wantz
ACS Appl. Mater. Interfaces, 2017, 9, 32405–32410

Wireless electrochemical actuation of conducting polymers
B. Gupta, B. Goudeau, A. Kuhn
Angew.Chem. Int. Ed. 2017, 56, 14183-14186

Indirect bipolar electrodeposition of polymers for the controlled design of zinc microswimmers
Z. Ali Fattah, L. Bouffier, A. Kuhn
Applied Materials Today 2017, 9, 259–265

Multi-scale modeling of diffusion and electrochemical reactions in porous micro-electrodes
T.D. Le, D. Lasseux, X.P. Nguyen, G. Vignoles, N. Mano, A. Kuhn
Chemical Engineering Science 2017, 173, 153–167

Surface Q1 enhancement of a molecularly imprinted polymer film using sacrificial silica beads for increasing L-arabitol chemosensor sensitivity and detectability
M. Dabrowski, M. Cieplak, K. Noworyta, M. Heim, W. Adamkiewicz, A. Kuhn, P. S. Sharma, W. Kutner
J. Mater. Chem. B, 2017,5, 6292-6299

Coupling electrochemistry with in situ fluorescence (confocal) microscopy
L. Bouffier, T. Doneux.
Current Opinion in Electrochemistry, DOI: 10.1016/j.coelec.2017.06.015.

Tracking nano-electrochemistry using individual plasmonic nanocavities
G. Di Martino,V. A. Turek, A. Lombardi, I. Szabó, B. de Nijs, A. Kuhn, E. Rosta, J.J. Baumberg
Nano Lett. 2017, 17, 4840-4845

2D Electrochemiluminescence: Light Emission Confined at the Oil/Water Interface in Emulsions Stabilized by Luminophore-Grafted Microgels
Rémy Bois, Sabina Scarabino, Valérie Ravaine, Neso Sojic
Langmuir, 2017, DOI: 10.1021/acs.langmuir.7b01585

Scanning Electrochemical Microscopy for BESs Characterizationors
D. Zigah, O. Fontaine
World Scientific 2017, ISBN: 978-1-78634-353-6

Biredox Ionic Liquids: New Opportunities Toward High Performances Supercapacitors
C. Bodin, E. Mourad, D. Zigah, S. Le Vot, S. A Freunberger, F. Favier, O. Fontaine
Faraday Discuss 2017, DOI: 10.1039/C7FD00174F

Anisotropic Metal Deposition on TiO2 Particles by Electric Field Induced Charge Separation
S. Tiewcharoen, C. Warakulwit, V. Lapeyre, P. Garrigue, L. Fourier, C. Elissalde, S. Buffière, P. Legros, M. Gayot, J. Limtrakul, A. Kuhn
Angew.Chem.Int.Ed. 2017, HOT PAPER in press, DOI: 10.1002/anie.201704393

Plasmonic response and SERS modulation in electrochemical applied potentials
G. Di Martino, V. A. Turek, C. Tserkezis, A. Lombardi, A. Kuhn, J.J. Baumberg
Faraday Discuss. 2017, in press,doi 10.1039/C7FD00130D

On-chip enzymatic microbiofuel cell-powered integrated circuits
A. G. Mark, E. Suraniti, J. Roche, H. Richter, A. Kuhn, N. Mano, P. Fischer
Lab Chip 2017, 17, 1761 HOT PAPER

Bipolar Electrochemistry with Organic Single Crystals for Wireless Synthesis of Metal-Organic Janus Objects and Asymmetric Photovoltage Generation
I. Malytska, C. Mézière, M. Keilar, L. Hirsch, G. Wantz, N. Avarvari, A. Kuhn, L. Bouffier
Journal of Physical Chemistry C 2017, DOI: 10.1021/acs.jpcc.7b02678

Modulation of Wetting Gradients by Tuning the Interplay between Surface Structuration and Anisotropic Molecular Layers with Bipolar Electrochemistry
L. Bouffier, S. Reculusa, V. Ravaine, A. Kuhn.
ChemPhysChem 2017, DOI: 10.1002/cphc.201700398

Oil-in-microgel strategy for enzymatic-triggered release of hydrophobic drugs
C.A. Busatto, H. Labie, V. Lapeyre, R. Auzely-Velty, A. Perro, N. Casis, J. Luna, D.A. Estenoz, V. Ravaine
Journal of Colloid and Interface Science 2017, 493, 356-364

Capillary-assisted bipolar electrochemistry: a focused minireview
L. Bouffier, N. Sojic, A. Kuhn
Electrophoresis 2017

Hierarchical templating in deposition of semi-covalently imprinted inverse opal polythiophene film for femtomolar determination of human serum albumin
M. Dabrowski⁠, M. Cieplak⁠a⁠, P. Sindhu Sharma⁠, P. Borowicz⁠, K. Noworyta⁠, W. Lisowski⁠, F. D’Souza⁠⁠, A. Kuhn⁠, W. Kutner
Biosens.&Bioelectron 2017, 94, 155-161

Spatially-resolved multicolor bipolar electrochemiluminescence
H. Li, L. Bouffier, S. Arbault, A. Kuhn, C. F. Hogan, N. Sojic
Electrochemistry Communications 2017, 77, 10-13

Co(III) Complexes of (1,3-Selen-2-yl)hydrazones and Their Sulphur Analogues: Comparative Structural, Electrochemical, Computational and Biological Activity Study
N. R. Filipović, H. Elshaflu, S. Grubišić, L. S. Jovanović, M. Rodić, I. Novaković, A. Malešević, I. S. Djordjević, H. Li, N. Šojić, A. Marinković, T. R. Todorović
Dalton Trans 2017, DOI: 10.1039/C6DT04785H

Efficient Annihilation Electrochemiluminescence of Cationic Helicene Luminophores
H. Li, S. Voci, A. Wallabregue, C. Adam, G. M. Labrador, R. Duwald, I. H. Delgado, S. Pascal, J. Bosson, J. Lacour, L. Bouffier, N. Sojic
ChemElectroChem 2017, DOI: 10.1002/celc.201600906

Applications of Electrogenerated Chemiluminescence in Analytical Chemistry
N. Sojic, S. Arbault, L. Bouffier, A. Kuhn
Luminescence in Electrochemistry. Applications in Analytical Chemistry, Physics and Biology. Eds. F. Miomandre, P. Audeber 2017

Recent Advances in Bipolar Electrochemistry
L. Bouffier, D. Zigah, N. Sojic, A. Kuhn
Electroanalytical Chemistry: A Series of Advances, Volume 27, eds. A.J. Bard, C.G. Zosk 2017

Low-Molecular-Weight Hydrogels as New Supramolecular Materials for Bioelectrochemical Interfaces
D. Jain, A. Karajic, M. Murawska, B. Goudeau, S. Bichon, S. Gounel, N. Mano, A. Kuhn, P. Barthélémy
ACS Appl. Mater. Interfaces 2017, 9, 1093-1098

Highly Ordered Macroporous Electrodes
A. Kuhn, M. Heim Springer Handbook of Electrochemical Energy, eds. C. Breitkopf, K. Swider-Lyons
Chapter 6 Springer Verlag, Berlin 2017, 143-206

Full-Spectral Multiplexing of Bioluminescence Resonance Energy Transfer in Three TRPV Channels
H. J. Ruigrok, G. Shahid, B. Goudeau, F. Poulletier de Gannes,E. Poque-Haro, A. Hurtier, I. Lagroye, P. Vacher, S. Arbault, N. Sojic, B. Veyret, Y. Percherancier
Biophysical Journal 2017, 112, 87–98

Bright Electrochemiluminescence Tunable in the Near-Infrared of Chiral Cationic Helicene Chromophores
H. Li, A. Wallabregue, C. Adam, G. M. Labrador, J. Bosson, L. Bouffier, J. Lacour, N. Sojic
J. Phys. Chem. C 2017, 121, 785-792

Drainage dynamics of thin-liquid films containing soft PNiPAM microgels : influence of the cross-linking density and concentration
L. Keal, V. Lapeyre, V. Ravaine, V. Schmitt and C. Monteux
Soft Matter 2017, 13, 170-180

Address & contact number

Address : ENSCBP, Building A, 1st floor
Email :
Phone : + 33 5 40 00 22 39
Site Web :


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