Analytical NanoSystems (NSysA)

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Group presentation

Our group is located at the National Engineering School of Chemistry, Biology and Physics (ENSCBP). The main activities are focused on the development of new analytical tools and techniques with a special accent on miniaturized systems applied to the study of biological systems and biomedical issues. Our research addresses problems resulting from the ever increasing demands of our modern society concerning various aspects like public health, security and environmental issues. In order to tackle these problems, the discipline of Analytical Chemistry has to evolve constantly and improve its performance.

Distinguishing molecules with almost identical physico-chemical properties, tracking their evolution with a high spatio-temporal resolution, detecting them at the cell or subcellular level in complex environments, are some of the challenges that we work on. With this respect current projects include biofunctionalized nanoparticles, chemical sensors for biology, electrochemistry of biosystems, micro/nanoscale imaging and smart functional nanostructures. In order to work successfully on these topics we have combined in our group an interdisciplinary team with know-how ranging from electrochemistry and optics to organic or colloidal synthesis and cell biology. The resulting synergy is the guaranty for original systems dedicated to contribute to the solution of some of the current problems in the field of Analytical Chemistry.

Research activity

> Functional surfaces & materials.
> Electrochemistry & light.
> Colloids & soft matter.
> Biological & biochemical systems.

Key Words

Electrochemistry, biochemistry, soft matter, colloids, optics, spectroscopy, micro/nanomaterials, chemical sensors, biosensors, supramolecular chemistry, fluorescence, electrochemiluminescence, neurotransmitters, electrochemical imaging, microgels, drug delivery, stimuli-responsive polymers, glucose, porous electrodes, Janus particles, bipolar electrochemistry, single cell electrochemistry.

Group members

Dr. Laurent Bouffier (CNRS Researcher & Group Leader)
Mrs. Laëtitia Debord (INP Administrator)
Mr. Patrick Garrigue (INP Engineer)
Dr. Bertrand Goudeau (CNRS Assistant Engineer)
Pr. Alexander Kuhn (INP Professor)
Mrs. Véronique Lapeyre (UB Assistant Engineer)
Dr. Adeline Perro (IPB Assistant Professor)
Pr. Valérie Ravaine (INP Professor)
Pr. Neso Sojic (INB Professor)

Brivatech: Technology Transfer

Dr. Stéphane Reculusa (ADERA Engineer)

Recent publications

Self-Assembly of Colloidal Polymers from Two-Patch Silica Nanoparticles
W. Li, C. Hubert, A. Perro, E. Duguet, S. Ravaine
Nano Res., 2020, 13, 3371-3376.

Large Scale Chirality Transduction with Functional Molecular Materials
S. Arnaboldi, B. Gupta, T. Benincori, G. Bonetti, R. Cirilli, A. Kuhn
Chem. Mater., 2020, 32(24), 10663-10669.

Highly Defective Carbon Nanotubes for Sensitive, Low-Cost and Environmentally Friendly Electrochemical H2O2 Sensors: Insight into Carbon Supports
M. Niamlaem, C. Boonyuen, W. Sangthong, J. Limtrakul, D. Zigah, A. Kuhn, C. Warakulwit
Carbon, 2020, 170, 154-164.

Electrochemistry Based Light-Emitting Mobile Systems
G. Salinas, I.-A. Pavel, N. Sojic, A. Kuhn
ChemElectroChem, 2020, 7(24), 4853-4862.

Wireless Enhanced Electrochemiluminescence at a Bipolar Microelectrode in a Solid-State Micropore
S. Voci, A. Ismail, P. Pham, J. Yu, A. Maziz, F. Mesnilgrente, L. Reynaud, T. Livache, P. Mailley, A. Buhot, T. Leichle, A. Kuhn, L. Leroy, A. Bouchet-Spinelli, N. Sojic
J. Electrochem. Soc., 2020, 167(13), 2020, 137509.

Light and Electric Field Induced Unusual Large-Scale Charge Separation in Hybrid Semiconductor Objects
A. A. Melvin, E. Lebraud, P. Garrigue, A. Kuhn
Phys. Chem. Chem. Phys., 2020, 22(39), 22180-22184.

Spatially Resolved Electrochemiluminescence Through Chemical Lens
A. Fiorani, D. Han, D. Jiang, D. Fang, F. Paolucci, N. Sojic, G. Valenti
Chem. Sci., 2020, 11(38), 10496-10500.

Reactivity Mapping of Luminescence in Space: Insights into Heterogeneous Electrochemiluminescence Bioassays
P. Dutta, D. Han, B. Goudeau, D. Jiang, D. Fang, N. Sojic
Biosens. Bioelectron., 2020, 165, 112372.

To Be, or Not to Be...Electrochemist?
A. Kuhn
J. Solid State Electrochem., 2020, 24, 2113-2114.

Enhancing the Sensitivity of Plasmonic Optical Fiber Sensors by Analyzing the Distribution of the Optical Modes Intensity
K. Vindas, A. Buhot, T. Livache, P. Garrigue, N. Sojic, L. Leroy, E. Engel
Opt. Express, 2020, 28(20), 28740-28749.

Near-Infrared Electrochemiluminescence in Water Through Regioselective Sulfonation of Diaza [4] and [6]Helicene Dyes
H. Li, R. Duwald, S. Pascal, S. Voci, C. Besnard, J. Bosson, L . Bouffier, J. Lacour, N. Sojic
Chem. Commun., 2020, 56(68), 9771-9774.

Luminescence Amplification at BiVO4 Photoanodes by Photoinduced Electrochemiluminescence
J. Yu, H. Saada, R. Abdallah, G. Loget, N. Sojic
Angew. Chem. Int. Ed., 2020, 59(35), 15157-15160.

Dynamic Covalent Chemistry Enables Reconfigurable All‐Polysaccharide Nanogels
F. Abdi, R. Michel, R. Poirot, M. Dakir, L. Sancey, V. Ravaine, R. Auzély‐Velty
Macromol. Rapid Commun., 2020, 41(15), 2000213.

Digitization and Image-Based Structure-Properties Relationship Evaluation of a Porous Gold Micro-Electrode
A. Baux, G. Couégnat, G. L. Vignoles, D. Lasseux, A. Kuhn, C. Carucci, N. Mano, T. D. Le
Mater. Design, 2020, 193, 108812

Chiral Macroporous MOF Surfaces for Electroassisted Enantioselective Adsorption and Separation
D. Suttipat, S. Butcha, S. Assavapanumat,T. Maihom, B. Gupta, A. Perro, N. Sojic, A. Kuhn, C. Wattanakit
ACS Appl. Mater. Interfaces, 2020, 12(32), 36548-36557.

Electrochemiluminescence Reaction Pathways in Nanofluidic Devices
S. Voci, H. Al-Kutubi, L. Rassaei, K. Mathwig, N. Sojic
Anal. Bioanal. Chem., 2020, 412(17), 4067-4075.

Asymmetry Controlled Dynamic Behavior of Autonomous Chemiluminescent Janus Microswimmers
G. Salinas, A. L. Dauphin, S. Voci, L. Bouffier, N. Sojic, A. Kuhn
Chem. Sci., 2020, 11(28), 7438-7443.

Quantum Nuts: Two Shells Are Better than One to Achieve Highly Efficient Electrochemiluminescence
L. Bouffier, N. Sojic
ACS Cent. Sci., 2020, 6(7), 1043-1045.

Absolute Chiral Recognition with Hybrid Wireless Electrochemical Actuators
S. Arnaboldi, B. Gupta, T. Benincori, G. Bonetti, R. Cirilli, A. Kuhn
Anal. Chem., 2020, 92(14), 10042-10047.

Photophysics, Electrochemistry and Efficient Electrochemiluminescence of Trigonal Truxene-core Dyes
S. Voci, J.-B. Verlhac, F. Polo, G. Clermont, J. Daniel, F. Castet, M. Blanchard-Desce, N. Sojic
Chem. Eur. J., 2020, 26(38), 8407-8416.

Na+ Ion Selectivity Study of a Crown Ether Functionalized PEDOT Analog
G. Salinas, A. Villarroel Marquez, M. Idir, S. Shinde, B. A. Frontana-Uribe, M. Raoux, J. Lang, E. Cloutet, A. Kuhn
ChemElectroChem, 2020, 7(13), 2826-2830.

Intracellular Wireless Analysis of Single Cells by Bipolar Electrochemiluminescence Confined in Nanopipette
Y. Wang, R. Jin, N. Sojic, D. Jiang, H.-Y. Chen
Angew. Chem. Int. Ed., 2020, 59(26), 10416-10420.

Chiroptical Detection of a Model Ruthenium Dye in Water by Circularly Polarized-Electrochemiluminescence
S. Voci, F. Zinna, L. Arrico, S. Grass, L. Bouffier, J. Lacour, L. Di Bari, N. Sojic
Chem. Commun., 2020, 56(44), 5989-5992.

Design of Potassium Selective Mixed Ion/Electron Conducting Polymers
A. Villarroel Marquez, G. Salinas, M. Abarkan, M. Idir, C. Brochon, G. Hadziioannou, M. Raoux, A. Kuhn, J. Lang, E. Cloutet
Macromol. Rapid Commun., 2020, 41(12), 2070030.

Wireless in Vivo Biofuel Cell Monitoring
L. Di Trocchio, C. Carucci, K.R. Sindhu, C. Morel, J.-L. Lachaud, S. Bichon, S. Gounel, N. Mano, C. Boiziau, C. Dejous, A. Kuhn, S. Hemour
IEEE J. Electromagn., RF, Microw. Med. Biol., 2020, doi: 10.1109/JERM.2020.2998325.

Enzymatic Glucose-Oxygen Biofuel Cells for Highly Efficient Interfacial Corrosion Protection
A. Karajic, P. Merzeau, E. Suraniti, S. Gounel, C. Jaillet, A. Kuhn, N. Mano
ACS Appl. Energy Mater., 2020, 3(5), 4441-4448.

Oscillatory Light-Emitting Biopolymer based Janus Microswimmers
R. María-Hormigos, A. Escarpa, B. Goudeau, V. Ravaine, A. Perro, A. Kuhn
Adv. Mater. Interfaces 2020, 2020, 7(10), 1902094.

In Situ Fluorescence Tomography Enables a 3D Mapping of Enzymatic O2 Reduction at the Electrochemical Interface
B. Tassy, A. L Dauphin, H. Mun Man, H. Le Guenno, E. Lojou, L. Bouffier, A. de Poulpiquet
Anal. Chem., 2020, 92(10), 7249-7256.

Self-Enhanced Multicolor Electrochemiluminescence by Competitive Electron-transfer Processes
S. Voci, R. Duwald, S. Grass, D. J. Hayne, L. Bouffier, P. S. Francis, J. Lacour, N. Sojic
Chem. Sci., 2020, 11(17), 4508-4515.

Chemo- and Magnetotaxis of Self-Propelled Light-Emitting Chemoelectronic Swimmers
G. Salinas, A. L. Dauphin, C. Colin, E. Villani, S. Arbault, L. Bouffier, A. Kuhn
Angew. Chem. Int. Ed., 2020, 59(19), 7508-7513.

Electrochemiluminescence in Thermo-Responsive Hydrogel Films with Tunable Thickness
H. Li, V. Ravaine, N. Sojic
J. Anal. Test., 2020, 4(2), 107-113.

Remote Actuation of a Light‐Emitting Device Based on Magnetic Stirring and Wireless Electrochemistry
A. L. Dauphin, S. Arbault, A. Kuhn, N. Sojic, L. Bouffier
ChemPhysChem, 2020, 21(7), 600-604.

Encoding Chiral Molecular Information in Metal Structures
C. Wattanakit, A. Kuhn
Chem. Eur. J., 2020, 26(14), 2993-3003.

Sugar-Responsive Pickering Emulsions Mediated by Switching Hydrophobicity in Microgels
M.-C. Tatry, Y. Qiu, V. Lapeyre, P. Garrigue, V. Schmitt, V. Ravaine
J. Colloid Interface Sci., 2020, 561, 481-493.

Electrosynthesis of Gradient TiO2 Nanotubes and Rapid Screening Using Scanning PhotoElectroChemical Microscopy
F. Gelb, Y-C. Chueh, N. Sojic, V. Keller, D. Zigah, T. Cottineau
Sustain. Energy Fuels, 2020, 4(3), 1099-1104.

Multiplexed Remote SPR Detection of Biological Interactions through Optical Fiber Bundles
C. Desmet, K. Vindas, R. Alvarado Meza, P. Garrigue, S. Voci, N. Sojic, A. Maziz, R. Courson, L. Malaquin, T. Leichle, A. Buhot, Y. Roupioz, L. Leroy, E. Engel
Sensors, 2020, 20(2), 511.

Address & contact number

Address : ENSCBP, Building A, 1st floor
Email :
Phone : + 33 5 56 84 79 05 / + 33 5 56 84 79 13
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