Analytical NanoSystems (NSysA)

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Group presentation

Our group is located at the National Engineering School of Chemistry, Biology and Physics (ENSCBP). The main activities are focused on the development of new analytical tools and techniques with a special accent on miniaturized systems applied to the study of biological systems and biomedical issues. Our research addresses problems resulting from the ever increasing demands of our modern society concerning various aspects like public health, security and environmental issues. In order to tackle these problems, the discipline of Analytical Chemistry has to evolve constantly and improve its performance.

Distinguishing molecules with almost identical physico-chemical properties, tracking their evolution with a high spatio-temporal resolution, detecting them at the cell or subcellular level in complex environments, are some of the challenges that we work on. With this respect current projects include biofunctionalized nanoparticles, chemical sensors for biology, electrochemistry of biosystems, micro/nanoscale imaging and smart functional nanostructures. In order to work successfully on these topics we have combined in our group an interdisciplinary team with know-how ranging from electrochemistry and optics to organic or colloidal synthesis and cell biology. The resulting synergy is the guaranty for original systems dedicated to contribute to the solution of some of the current problems in the field of Analytical Chemistry.

Research activity

> Chemical sensors for biology (molecular probes for detection of bio-relevant species, electrochemical biosensors).
> Micro/nanoscale imaging (optical tools for imaging & enhanced coupled methodologies, electrochemical imaging).
> Smart functional nanostructures (micro/nanogels for drug delivery, nanostructured electrodes, functional inorganic particles).
> Electrochemistry of biosytems (cell & sub-cellular analysis, protein/peptide electrochemistry, electron transfer in DNA).

Key Words

Electrochemistry, biochemistry, inorganic and organic synthesis, soft matter, colloids, optics, spectroscopy, micro/nanomaterials, chemical sensors, biosensors, supramolecular chemistry, fluorescence, electrochemiluminescence, neurotransmitters, electrochemical imaging, microgels, drug delivery, stimuli-responsive polymers, glucose, porous electrodes, Janus particles, bipolar electrochemistry, single cell electrochemistry, reactive oxygen and nitrogen species, mitochondria, DNA, peptides.

Group members

Dr. Valérie Ravaine (INP Professor & Group Leader)
Mrs. Cécile Alliaire (INP Administrator)
Dr. Stéphane Arbault (CNRS Research Director)
Dr. Laurent Bouffier (CNRS Researcher)
Mr. Patrick Garrigue (INP Engineer)
Dr. Bertrand Goudeau (CNRS Assistant Engineer)
Pr. Alexander Kuhn (INP Professor)
Mrs. Véronique Lapeyre (UB Assistant Engineer)
Dr. Adeline Perro-Marre (IPB Assistant Professor)
Mrs. Aline Simon-Lalande (INP Administrator)
Pr. Neso Sojic (INB Professor)
Dr. Dodzi Zigah (UB Assistant Professor)

Brivatech: Technology Transfer

Dr. Stéphane Reculusa (ADERA Engineer)

Recent publications

Rational Design of Enzyme‐Modified Electrodes for Optimized Bioelectrocatalytic Activity
L. Zhang, C. Carucci, S. Reculusa, B. Goudeau, P. Lefrançois, S. Gounel, N. Mano, A. Kuhn
ChemElectroChem , 2019

Self-coacervation of ampholyte polymer chains as an efficient encapsulation strategy.
A. Perro, L. Giraud, N. Coudon, S. Shanmugathasan, B. Goudeau, J.-P. Douliez and V. Ravaine
Journal of Colloid and Interface Science , 2019, 548, 275-283

Kinetics of spontaneous microgels adsorption and stabilization of emulsions produced using microfluidics
M.-C. Tatry, E. Laurichesse, A. Perro, V. Ravaine and V. Schmitt
Journal of Colloid and Interface Science , 2019, 548, 1-11

Adsorption of Proteins on Dual Loaded Silica Nanocapsules
S. Ramalingam, G. Le Bourdon, E. Pouget, A. Scalabre, J. Raghava Rao and A. Perro
J. Phys. Chem B , 2019; 123 (7), 1708-1717

Sealing hyaluronic acid microgel with oppositely-charged polypeptide: a simple strategy for packaging hydrophilic drugs with on-demand release.
H. Labie, A. Perro, V. Lapeyre, B. Goudeau, B. Catargi, R. Auzély, V. Ravaine
Journal of Colloid and Interface Science, 2019 535, 16-27

Circularly Polarized-Electrochemiluminescence from a Chiral Bispyrene Organic Macrocycle
F. Zinna, S. Voci, L. Arrico, E. Brun, A. Homberg, L. Bouffier, T. Funaioli, J. Lacour, N. Sojic, L. Di Bari
Angew. Chem. Int. Ed., 2019

Towards determining Kinetics of Annihilation electrogenerated Chemiluminescence by concentration-dependent luminescent Intensity
K. Mathwig, N. Sojic
Journal of Analysis and Testing, 2019

Highly-Parallel Remote SPR Detection of DNA Hybridization by Micropillar Optical Arrays
K. Vindas, L. Leroy, P. Garrigue, S. Voci, T. Livache, S. Arbault, N. Sojic, A. Buhot, E. Engel
Anal. Bioanal. Chem., 2019

Electrochemiluminescence Imaging for Bioanalysis
J. Zhang, S. Arbault, N. Sojic, D. Jiang
Annu. Rev. Anal. Chem , 2019, 12

Wireless coupling of conducting polymer actuators with light emission
B. Gupta, M. C. Afonso, L. Zhang, C. Ayela, P. Garrigue, B. Goudeau, A. Kuhn
ChemPhysChem , 2019, 7, 265

Facile Fabrication of Surface-Imprinted Macroporous Films for Chemosensing of Human Chorionic Gonadotropin Hormone
M. Dąbrowski, A. Ziminska, J. Kalecki, M. Cieplak, W. Lisowski, R. Maksym, S. Shao, F. D’Souza, A. Kuhn, P. S. Sharma
ACS Applied Materials and Interfaces , 2019, 11, 265

Wireless Addressing of Freestanding MoSe2 Macro- and Microparticles by Bipolar Electrochemistry
S. Voci, B. Goudeau, G. Valenti, A. Lesch, M. Jović, S. Rapino, F. Paolucci, S. Arbault, N. Sojic
J. Phys. Chem. C, 2019

Bipolar Conducting Polymer Crawlers Based on Triple Symmetry Breaking
B. Gupta, B. Goudeau, P. Garrigue, A. Kuhn
Adv. Funct. Mater. , 2018, 1705825

Sealing hyaluronic acid microgels with oppositely-charged polypeptides: A simple strategy for packaging hydrophilic drugs with on-demand release
H. Labie, A. Perro, V. Lapeyre, B. Goudeau, B. Catargi, R. Auzély, V. Ravaine
Journal of Colloid and Interface Science , 2019, 535, 16-27

Potential Induced Fine-tuning the Enantioaffinity of Chiral Metal Phases
S. Assavapanumat, T. Yutthalekha, P. Garrigue, B. Goudeau, V. Lapeyre, A. Perro, N. Sojic, C. Wattanakit, A. Kuhn
Angew. Chem. Int. Ed. , 2019, 58, 3471

Surface-confined Electrochemiluminescence Microscopy of Cell Membranes
I. Malytska, Th. Doneux, M. Bougouma, A. Kuhn, L. Bouffier
J. Am. Chem. Soc. , 2018, 140, 14753-14760

Enhanced Annihilation Electrochemiluminescence by Nanofluidic Confinement
Hanan Al-Kutubi, Silvia Voci, Liza Rassaei, Neso Sojic, Klaus Mathwig
Chemical Science, 2018, 9, 8946-8950

L’électrochimiluminescence : une méthode de choix pour la bioanalyse
L. Bouffier, S. Arbault, A. Kuhn, N. Sojic
Techniques de l’Ingénieur , 2018, 156

Poly(aspartic acid) hydrogels showing reversible volume change upon redox stimulus
E.Krisch, B. Gyarmati, D. Barczikai, V. Lapeyre, B.A. Szilágyi, V. Ravaine, A. Szilágyi
European Polymer Journal , 2018, 105, 459-468 _
Wireless electromechanical readout of chemical information
L. Zhang, B. Gupta, B. Goudeau, N. Mano, A. Kuhn
J. Am. Chem. Soc , 2018, 90, 140, 15501

Preparation of Template-Free Robust Yolk–Shell Gelled Particles from Controllably Evolved All-in-Water Emulsions
J.-P. Douliez, A. Perro, J.-P. Chapel, B. Goudeau and L. Béven
Small , 2018, 90, 1803042

Highly ordered macroporous poly-3,4-ortho-xylendioxythiophene electrodes as a sensitive analytical tool for heavy metal quantification
G. Salinas, B. A. Frontana-Uribe, S. Reculusa, P. Garrigue, A. Kuhn
Anal.Chem, 2018, 90, 11770

Optimal thickness of a porous micro‐electrode operating a single redox reaction
T. D. Le, L. Zhang, S. Reculusa, G.Vignoles, N. Mano, A. Kuhn, D. Lasseux
ChemElectroChem, 2018, 6, 173

A snapshot of the electrochemical reaction layer by using 3 dimensionally resolved fluorescence mapping
A. de Poulpiquet, B. Goudeau, P. Garrigue, N. Sojic, S. Arbault, T. Doneux, L. Bouffier
Chem. Sci. , 2018, 9, 6622-6628

Eosin-Mediated Alkylsulfonyl Cyanation of Olefins
V. Pirenne, G. Kurtay, S. Voci, L. Bouffier, N. Sojic, F. Robert, D. M. Bassani, Y. Landais
Org. Lett. , 2018, 20 (15), 4521-4525

C‐Functionalized Cationic Diazaoxatriangulenes: Late‐Stage Synthesis and Tuning of Physicochemical Properties
I. Hernández Delgado, S. Pascal, C. Besnard, S. Voci, L. Bouffier, N. Sojic, J. Lacour.
Chem. Eur. J. , 2018, 24 (40), 10186-10195.

Uphill production of dihydrogen by enzymatic oxidation of glucose without an external energy source
E. Suraniti, P. Merzeau, J. Roche, S. Gounel, A. G. Mark, P. Fischer, N. Mano, A. Kuhn
Nature Comm. , 2018, 9:3229

Electrically Controlled Nano and Micro Actuation in Memristive Switching Device with On-Chip Gas Encapsulation
D. Kos, H. P. A. G. Astier, G. D. Martino, J. Mertens, H. Ohadi, D. De. Fazio, D. Yoon, Z. Zhao, A. Kuhn, A. C. Ferrari, C. J. B. Ford, J. J. Baumberg
Small, 2018, 1801599

TRPV1 activation induced by modulated or unmodulated 1800 MHz radiofrequency field exposure
Ruigrok, H.J., Arnaud-Cormos D., Hurtier A., Poque-Haro E., Poulletier de Gannes F., Ruffié G., Bonnaudin F, Lagroye I., Sojic N., Arbault S., Lévêque P., Veyret B. and Percherancier Y.
Radiation Research, 2018, 189, 95-103,

Correlations between gaseous and liquid phase chemistries induced by cold atmospheric plasmas in a physiological buffer
Girard F., Peret M., Dumont N., Badets V., Blanc S., Gazeli K., Noël C., Belmonte T., Marlin L., Cambus J.P., Simon G., Sojic N., Held B., Clément F. and Arbault S
Phys. Chem. Chem. Phys., 2018, 20, 9197-9210

Electroformation of Phospholipid Giant Unilamellar Vesicles in a Physiological Buffer
Lefrançois P., Goudeau B., Arbault S.
Integrative Biology, 2018, 7, 429-434,

Des biopiles enzymatiques pour alimenter des circuits électroniques implantables
E. Suraniti, A.G. Mark, J. Roche, H. Richter, A. Kuhn, P. Fischer, N. Mano
L’Actualité Chimique, 2018, 427-428,127-128

Address & contact number

Address : ENSCBP, Building A, 1st floor
Email :
Phone : + 33 5 40 00 22 39
Site Web :


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